Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate receptor 1 (adult) | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 19 (folate transporter), member 1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 46 (folate transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | folate receptor beta | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma japonicum | Folate receptor beta precursor, putative | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Echinococcus granulosus | folate receptor beta | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Schistosoma japonicum | IPR011701,Major facilitator superfamily MFS_1,domain-containing | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1497 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.0503 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0124 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 109 nM | Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
IC50 (binding) | = 116 nM | Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
IC50 (binding) | = 312 nM | Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
IC50 (ADMET) | > 1000 nM | Cytotoxicity against RFC-deficient Chinese hamster R2 cells assessed as growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
Inhibition (binding) | Inhibition of GARFTase/AICARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as cell growth inhibition at 1 to 1000 nM after 96 hrs by CellTiter-Blue assay in presence of 60 uM adenosine | ChEMBL. | 25602637 | |
Inhibition (binding) | Inhibition of AICARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as cell growth inhibition at 1 to 1000 nM after 96 hrs by CellTiter-Blue assay in presence of 320 uM AICA | ChEMBL. | 25602637 | |
Inhibition (binding) | Inhibition of GARFTase/AICARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as cell growth inhibition at 1 to 1000 nM after 96 hrs by CellTiter-Blue assay in presence of 10 uM thymidine | ChEMBL. | 25602637 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25602637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.