Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 19 (folate transporter), member 1 | Starlite/ChEMBL | References |
Homo sapiens | folate receptor 1 (adult) | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 46 (folate transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | folate receptor beta | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma japonicum | IPR011701,Major facilitator superfamily MFS_1,domain-containing | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | Get druggable targets OG5_133613 | All targets in OG5_133613 |
Schistosoma japonicum | Folate receptor beta precursor, putative | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Echinococcus granulosus | folate receptor beta | Get druggable targets OG5_133376 | All targets in OG5_133376 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0396 | 0.2434 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0061 | 0.0228 | 0.5 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0061 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Giardia lamblia | Hypothetical protein | 0.0061 | 0.0228 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Toxoplasma gondii | hypothetical protein | 0.0124 | 0.0642 | 0.5 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.0061 | 0.0228 | 0.0939 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0061 | 0.0228 | 1 |
Onchocerca volvulus | 0.0061 | 0.0228 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | 0.0181 | 0.1017 | 0.1017 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Onchocerca volvulus | 0.0061 | 0.0228 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.2434 | 1 |
Onchocerca volvulus | 0.0061 | 0.0228 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1016 | 1 |
Brugia malayi | folate-like transporter 3 | 0.0061 | 0.0228 | 0.0939 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1545 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Brugia malayi | Reduced folate carrier family protein | 0.0061 | 0.0228 | 0.0939 |
Echinococcus granulosus | folate receptor beta | 0.0503 | 0.3139 | 0.3139 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0396 | 0.2434 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0396 | 0.2434 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.0503 | 0.3139 | 0.3139 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0396 | 0.2434 | 0.5 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | 0.0181 | 0.1017 | 0.1017 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0061 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0228 | 0.0939 |
Onchocerca volvulus | 0.0061 | 0.0228 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
IC50 (binding) | > 1000 nM | Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
IC50 (binding) | > 1000 nM | Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
IC50 (ADMET) | > 1000 nM | Cytotoxicity against RFC-deficient Chinese hamster R2 cells assessed as growth inhibition after 96 hrs by CellTiter-Blue assay | ChEMBL. | 25602637 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25602637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.