Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Plasmodium falciparum | sortilin | 0.0041 | 1 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0028 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0028 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0028 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | sortilin | 0.0029 | 0.0803 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | putative neuropeptide receptor | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | sortilin, putative | 0.0041 | 1 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Echinococcus multilocularis | sortilin | 0.0041 | 1 | 1 |
Plasmodium vivax | sortilin, putative | 0.0041 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0028 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (binding) | < 10 uM | Activation of AMPK (unknown origin) using ACC1 as substrate after 60 mins | ChEMBL. | 25122135 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.