Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3719 | 0.4609 | 0.4609 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.7878 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.7878 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3719 | 0.4609 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0168 | 0.0006 | 0.0006 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.7878 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0168 | 0.0006 | 0.0006 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3719 | 0.4609 | 0.5 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0829 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0168 | 0.0006 | 0.0006 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.7878 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3719 | 0.4609 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0168 | 0.0006 | 0.0006 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0168 | 0.0006 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0168 | 0.0006 | 0.0006 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.7878 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0168 | 0.0006 | 0.0006 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0829 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0006 | 0.0006 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0829 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | serotonin transporter b | 0.0168 | 0.0006 | 0.0006 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0168 | 0.0006 | 0.0006 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.3719 | 0.4609 | 0.4609 |
Loa Loa (eye worm) | hypothetical protein | 0.1901 | 0.2252 | 0.2252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.