Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0055 | 0.049 | 0.049 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0055 | 0.049 | 0.1133 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0055 | 0.049 | 0.1133 |
Brugia malayi | hypothetical protein | 0.0075 | 0.1025 | 0.1025 |
Echinococcus multilocularis | GPCR, family 2 | 0.0055 | 0.049 | 0.1133 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.4328 | 1 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0337 | 0.7944 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0116 | 0.2113 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0055 | 0.049 | 0.1133 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0.0518 | 0.245 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0127 | 0.2407 | 0.303 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0165 | 0.0381 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0127 | 0.2407 | 0.303 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0142 | 0.2783 | 0.3503 |
Plasmodium vivax | glutathione reductase, putative | 0.0056 | 0.0518 | 0.0652 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0055 | 0.049 | 0.049 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0116 | 0.2113 | 1 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0337 | 0.7944 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0127 | 0.2407 | 0.303 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.4328 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0056 | 0.0518 | 0.0518 |
Echinococcus granulosus | GPCR family 2 | 0.0055 | 0.049 | 0.1133 |
Brugia malayi | glutathione reductase | 0.0056 | 0.0518 | 0.0518 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0142 | 0.2783 | 0.0678 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.049 | 0.1133 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0165 | 0.0381 |
Toxoplasma gondii | thioredoxin reductase | 0.0056 | 0.0518 | 0.245 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0056 | 0.0518 | 0.0652 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0165 | 0.0165 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.217 | 0.5014 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.049 | 0.049 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0116 | 0.2113 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0165 | 0.5 |
Echinococcus granulosus | geminin | 0.02 | 0.4328 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0173 | 0.3618 | 0.3618 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0127 | 0.2407 | 0.303 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0165 | 0.0381 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.049 | 0.1133 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0116 | 0.2113 | 0.266 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0173 | 0.3618 | 0.3618 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0118 | 0.217 | 0.217 |
Brugia malayi | Thioredoxin reductase | 0.0056 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.3618 | 0.3618 |
Brugia malayi | Pax transcription factor protein 2 | 0.0284 | 0.655 | 0.655 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0052 | 0.042 | 0.097 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0284 | 0.655 | 0.655 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0056 | 0.0518 | 0.1196 |
Treponema pallidum | hypothetical protein | 0.0337 | 0.7944 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.049 | 0.1133 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0337 | 0.7944 | 1 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0337 | 0.7944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2113 | 0.2113 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0127 | 0.2407 | 0.303 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0165 | 0.0381 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0.0518 | 0.0652 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0055 | 0.049 | 0.1133 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0055 | 0.049 | 0.049 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0116 | 0.2113 | 0.266 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0116 | 0.2113 | 0.266 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.049 | 0.1133 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0337 | 0.7944 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0116 | 0.2113 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0056 | 0.0518 | 0.0518 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0165 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0142 | 0.2783 | 0.3503 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.217 | 0.217 |
Echinococcus multilocularis | geminin | 0.02 | 0.4328 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0165 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0056 | 0.0518 | 0.1196 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0052 | 0.042 | 0.097 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0142 | 0.2783 | 0.3503 |
Brugia malayi | hypothetical protein | 0.0116 | 0.2113 | 0.2113 |
Leishmania major | trypanothione reductase | 0.0056 | 0.0518 | 0.245 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.042 | 0.097 |
Trypanosoma brucei | trypanothione reductase | 0.0056 | 0.0518 | 0.245 |
Leishmania major | hypothetical protein, conserved | 0.0116 | 0.2113 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0165 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0056 | 0.0518 | 0.0652 |
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0.0518 | 0.0652 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0173 | 0.3618 | 0.3618 |
Mycobacterium tuberculosis | Probable reductase | 0.0127 | 0.2407 | 0.303 |
Onchocerca volvulus | 0.0284 | 0.655 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.