Detailed information for compound 1945038

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.663 | Formula: C27H43N5O
  • H donors: 1 H acceptors: 2 LogP: 8.47 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCc1ccc(cc1)c1noc(n1)[C@@H]1CCCN1C(=N)N
  • InChi: 1S/C27H43N5O/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-22-17-19-23(20-18-22)25-30-26(33-31-25)24-16-14-21-32(24)27(28)29/h17-20,24H,2-16,21H2,1H3,(H3,28,29)/t24-/m0/s1
  • InChiKey: ADKZEGGKCWTVKB-DEOSSOPVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.2294
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0119 0.0134 0.0134
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0276 0.0376 0.0376
Loa Loa (eye worm) ACC-1 protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0226 0.0299 0.0307
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0266 0.2368
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.005 0.0048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Brugia malayi excitatory GABA receptor EXP-1A 0.0119 0.0134 0.0132
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0119 0.0134 0.0132
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0134 0.0132
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.0305
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0205 0.0266 0.0265
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.2368
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0266 0.2294
Echinococcus granulosus sphingosine kinase 1 0.0369 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Loa Loa (eye worm) hypothetical protein 0.6335 0.9685 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0187 0.0192
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0023 0.0026
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0119 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Schistosoma mansoni calcium-activated potassium channel 0.0291 0.0399 0.3676
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.5352 0.8174 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0266 0.2294
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Brugia malayi hypothetical protein 0.0055 0.0036 0.0034
Loa Loa (eye worm) ACC-1 protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0205 0.0266 0.0273
Leishmania major hypothetical protein, conserved 0.0205 0.0266 0.2368
Brugia malayi follicle stimulating hormone receptor 0.0266 0.036 0.0359
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0205 0.0266 0.2448
Onchocerca volvulus 0.0119 0.0134 0.3464
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0036 0.0034
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0119 0.0134 0.0134
Echinococcus multilocularis nAChR subunit 0.0119 0.0134 0.0132
Echinococcus multilocularis small conductance calcium activated potassium 0.0369 0.0518 0.0516
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0736 0.1083 1
Toxoplasma gondii GAF domain-containing protein 0.0531 0.0768 0.0937
Loa Loa (eye worm) hypothetical protein 0.0205 0.0266 0.0273
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0205 0.0266 0.2368
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0196 0.18
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0736 0.1083 1
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.0768 0.7026
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0023 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Onchocerca volvulus 0.0281 0.0383 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0205 0.0266 0.0265
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0119 0.0134 0.0132
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0119 0.0134 0.0132
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0196 0.0195
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Brugia malayi hypothetical protein 0.0055 0.0036 0.0034
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0119 0.0134 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0266 0.2368
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0119 0.0134 0.0132
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Loa Loa (eye worm) PDE1B protein 0.0205 0.0266 0.0273
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0119 0.0134 0.1221
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Brugia malayi hypothetical protein 0.0055 0.0036 0.0034
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0119 0.0134 0.0132
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.019 0.019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus multilocularis glycine receptor subunit beta 0.0119 0.0134 0.0132
Leishmania major hypothetical protein, conserved 0.0205 0.0266 0.2368
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0205 0.0266 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.2294
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.036 0.037
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0736 0.1083 0.1083
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.5352 0.8174 1
Brugia malayi glutaminase DH11.1 0.0322 0.0446 0.0444
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0281 0.0383 0.3526
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Onchocerca volvulus Putative nachr subunit 0.0276 0.0376 0.9815
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0205 0.0266 0.0265
Entamoeba histolytica hypothetical protein, conserved 0.0369 0.0519 1
Onchocerca volvulus 0.0055 0.0036 0.0885
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.5352 0.8174 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0281 0.0383 0.3526
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0055 0.0036 0.0036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Echinococcus granulosus glycine receptor subunit alpha 1 0.0119 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0369 0.0518 0.4774
Brugia malayi Cation transporter family protein 0.0119 0.0134 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0266 0.2368
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.2368
Echinococcus granulosus small conductance calcium activated potassium 0.0369 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.5804 0.8869 0.9157
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Schistosoma mansoni multidrug resistance protein 0.004 0.0013 0.0104
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0205 0.0266 0.0265
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0276 0.0376 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.0768 0.7026
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0055 0.0036 0.0034
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0205 0.0266 0.2368
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.004 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0261 0.0352 0.3099
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0205 0.0266 0.0266
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0205 0.0266 0.2368
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0736 0.1083 0.1081
Plasmodium falciparum GAF domain-related protein, putative 0.0531 0.0768 0.092
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0119 0.0134 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0002 0.0002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.2294
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0276 0.0376 0.0376
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0119 0.0134 0.1221
Trichomonas vaginalis conserved hypothetical protein 0.0736 0.1083 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus granulosus glycine receptor subunit beta 0.0119 0.0134 0.0134
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0119 0.0134 0.1221
Onchocerca volvulus 0.0064 0.005 0.1255
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Brugia malayi hypothetical protein 0.0055 0.0036 0.0034
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.5352 0.8174 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0036 0.0034
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0119 0.0134 0.0132
Echinococcus granulosus glycine receptor subunit alpha 1 0.0119 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.0768 0.7026
Loa Loa (eye worm) hypothetical protein 0.0281 0.0383 0.0394
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Schistosoma mansoni nAChR subunit 0.0055 0.0036 0.0312
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) LGC-31 protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0281 0.0383 0.0394
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0119 0.0134 0.0132
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0205 0.0266 0.2368
Loa Loa (eye worm) hypothetical protein 0.0276 0.0376 0.0386
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0036 0.0312
Toxoplasma gondii hypothetical protein 0.0531 0.0768 0.0937
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.0303 0.0311
Brugia malayi Cation transporter family protein 0.0281 0.0383 0.0381
Onchocerca volvulus 0.0281 0.0383 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0205 0.0266 0.0265
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Toxoplasma gondii hypothetical protein 0.0531 0.0768 0.0937
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0055 0.0036 0.0034
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0736 0.1083 1
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.3561 0.5422 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0205 0.0266 0.0324
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0205 0.0266 0.0273
Onchocerca volvulus 0.0055 0.0036 0.0885
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0055 0.0036 0.0035
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0531 0.0768 0.0508
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.5352 0.8174 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Brugia malayi hypothetical protein 0.0055 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.5352 0.8174 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0119 0.0134 0.0132
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.5352 0.8174 0.5
Echinococcus multilocularis nAChR subunit 0.0064 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0055 0.0036 0.0034
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.0036 0.0312
Loa Loa (eye worm) GABA receptor subunit 0.0064 0.005 0.0049
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0119 0.0134 0.1221
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.0324
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0276 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.0064 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0531 0.0768 0.0508
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0119 0.0134 0.0132
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0205 0.0266 0.2294
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0205 0.0266 0.0305
Brugia malayi Pre-SET motif family protein 0.0229 0.0303 0.0301
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Onchocerca volvulus 0.0261 0.0352 0.9181
Echinococcus granulosus glycine receptor subunit alpha 1 0.0119 0.0134 0.0134
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.0305
Toxoplasma gondii hypothetical protein 0.0531 0.0768 0.0937
Brugia malayi Cation transporter family protein 0.0119 0.0134 0.0132
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0119 0.0134 0.0134
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0119 0.0134 0.0132
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus multilocularis sphingosine kinase 1 0.0369 0.0519 0.0517
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0205 0.0266 0.0265
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Mycobacterium ulcerans putative regulatory protein 0.0531 0.0768 0.0416
Schistosoma mansoni sphingosine kinase A B 0.0369 0.0519 0.478
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0736 0.1083 0.1081
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0266 0.2368
Onchocerca volvulus 0.0119 0.0134 0.3464
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0196 0.0195
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0134 0.0132
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0205 0.0266 0.0305
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0119 0.0134 0.0136
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0119 0.0134 0.0132
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0205 0.0266 0.0305
Loa Loa (eye worm) hypothetical protein 0.0138 0.0163 0.0167
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0023 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0531 0.0768 0.0937
Loa Loa (eye worm) acetylcholine receptor protein 0.0055 0.0036 0.0035
Loa Loa (eye worm) acetyltransferase 0.0159 0.0196 0.0201
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Onchocerca volvulus 0.0281 0.0383 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Trichomonas vaginalis conserved hypothetical protein 0.0531 0.0768 0.7026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0736 0.1083 1
Giardia lamblia Hypothetical protein 0.0205 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0736 0.1083 0.1116
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0119 0.0134 0.0132
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.005 0.0048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0119 0.0134 0.0136
Echinococcus granulosus nAChR subunit 0.0119 0.0134 0.0134
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.005 0.0443
Schistosoma mansoni glutaminase 0.0322 0.0446 0.411
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0064 0.005 0.0048
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Loa Loa (eye worm) glutaminase 0.0322 0.0446 0.0459
Trypanosoma brucei hypothetical protein, conserved 0.0205 0.0266 0.2368
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.004 0.0013 0.0013
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0055 0.0036 0.0034
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.2294
Echinococcus granulosus nAChR subunit 0.0064 0.005 0.005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0205 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0055 0.0036 0.0034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0134 0.0132
Loa Loa (eye worm) glutaminase 2 0.0322 0.0446 0.0459
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0205 0.0266 0.2294
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0055 0.0036 0.0034
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0205 0.0266 0.0266
Schistosoma mansoni nAChR subunit 0.0119 0.0134 0.1221
Loa Loa (eye worm) hypothetical protein 0.0369 0.0519 0.0534
Schistosoma mansoni acetylcholine receptor subunit beta 0.0055 0.0036 0.0312
Mycobacterium ulcerans hypothetical protein 0.0369 0.0519 0.0094
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.005 0.0443
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0205 0.0266 0.0266
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0134 0.0132
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0736 0.1083 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0276 0.0376 0.0374
Loa Loa (eye worm) hypothetical protein 0.0369 0.0518 0.0533
Trichomonas vaginalis glutaminase, putative 0.0322 0.0446 0.399
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0205 0.0266 0.0265
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0205 0.0266 0.0266
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0064 0.005 0.0443
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0134 0.0132
Onchocerca volvulus 0.0055 0.0036 0.0885
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0205 0.0266 0.0265
Loa Loa (eye worm) hypothetical protein 0.0119 0.0134 0.0136
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0205 0.0266 0.0265
Schistosoma mansoni calcium-activated potassium channel 0.0369 0.0518 0.4774
Leishmania major cAMP-specific phosphodiesterase, putative 0.0205 0.0266 0.2368
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0276 0.0376 0.0374
Plasmodium falciparum phosphodiesterase delta, putative 0.0205 0.0266 0.0305
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0119 0.0134 0.0132
Echinococcus multilocularis glycine receptor subunit beta 0.0119 0.0134 0.0132
Schistosoma mansoni acetylcholine receptor-related 0.0055 0.0036 0.0312
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Entamoeba histolytica hypothetical protein 0.0064 0.005 0.0644
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0205 0.0266 0.2368
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0205 0.0266 0.2448
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.005 0.0048
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0119 0.0134 0.0136
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0037 0.0008 0.0006
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0119 0.0134 0.0136
Onchocerca volvulus 0.0119 0.0134 0.3464
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0266 0.2368
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0055 0.0036 0.0036
Onchocerca volvulus 0.0064 0.005 0.1255
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Giardia lamblia hypothetical protein 0.0205 0.0266 1
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0266 0.2368
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0205 0.0266 0.2368
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0119 0.0134 0.0132
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus granulosus glycine receptor subunit beta 0.0119 0.0134 0.0134
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0119 0.0134 0.0134
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0205 0.0266 0.0273
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0055 0.0036 0.0035
Schistosoma mansoni sphingoid long chain base kinase 0.0369 0.0519 0.478
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.5352 0.8174 0.5
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0205 0.0266 0.2368
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.0324
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0205 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0062 0.0047 0.0047
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0205 0.0266 0.2448
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0276 0.0376 0.0376
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0736 0.1083 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0023 0.0023
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0205 0.0266 0.0324
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0119 0.0134 0.0132
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0205 0.0266 0.0324
Schistosoma mansoni nAChR subunit 0.0055 0.0036 0.0312
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0205 0.0266 0.2368
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0276 0.0376 0.0374
Mycobacterium ulcerans putative regulatory protein 0.0531 0.0768 0.0416
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0205 0.0266 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0531 0.0768 0.0416

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.