Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetyl-CoA carboxylase 1 | Starlite/ChEMBL | References |
Homo sapiens | acetyl-CoA carboxylase beta | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 64 ml/min.kg | Intrinsic clearance in human liver microsomes | ChEMBL. | 26411795 |
IC50 (binding) | = 0.31 uM | Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintillation counting analysis | ChEMBL. | 26411795 |
IC50 (binding) | = 0.88 uM | Inhibition of recombinant human ACC2 expressed in CHO cells by fluorescence polarization assay | ChEMBL. | 26411795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.