Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | No references |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | Get druggable targets OG5_131977 | All targets in OG5_131977 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, STE STE20 | 0.0019 | 0.0018 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0018 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0019 | 0.0018 | 0.002 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0018 | 0.002 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0018 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0018 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0018 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.9067 | 1 |
Brugia malayi | Protein kinase domain | 0.0019 | 0.0018 | 0.0018 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0018 | 1 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0018 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0018 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0221 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0018 | 0.002 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0018 | 0.002 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0018 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0019 | 0.0018 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.0018 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.9067 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0019 | 0.0018 | 0.002 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0019 | 0.0018 | 0.002 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0018 | 1 |
Schistosoma mansoni | protein kinase | 0.0019 | 0.0018 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0019 | 0.0018 | 0.002 |
Entamoeba histolytica | p21-activated kinase | 0.0019 | 0.0018 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 19 nM | BindingDB_Patents: Enzymatic Assay. The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an amino acid side chain of a commercially available peptide (amino acid sequence EVPRRKSLVGTPYWM). | ChEMBL. | No reference |
EC50 (binding) | = 19 nM | BindingDB_Patents: Enzymatic Assay. The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an amino acid side chain of a commercially available peptide (amino acid sequence EVPRRKSLVGTPYWM). | ChEMBL. | No reference |
Ki (binding) | = 3.5 nM | BindingDB_Patents: Enzymatic Assay. The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an amino acid side chain of a commercially available peptide (amino acid sequence EVPRRKSLVGTPYWM). | ChEMBL. | No reference |
Ki (binding) | = 3.5 nM | BindingDB_Patents: Enzymatic Assay. The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an amino acid side chain of a commercially available peptide (amino acid sequence EVPRRKSLVGTPYWM). | ChEMBL. | No reference |
Ki (binding) | = 3.5 nM | BindingDB_Patents: Enzymatic Assay. The enzymatic activity of PAK4 KD was measured by its ability to catalyzed the transfer of a phosphate residue from a nucleoside triphosphate to an amino acid side chain of a commercially available peptide (amino acid sequence EVPRRKSLVGTPYWM). | ChEMBL. | No reference |
Ki (binding) | = 59 nM | BindingDB_Patents: Binding Assay. Binding assay of certain compounds of this invention to the opioid receptor was determine using radioligand binding assay (screening and dose-displacement). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.