Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypocretin (orexin) receptor 2 | Starlite/ChEMBL | No references |
Homo sapiens | hypocretin (orexin) receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus granulosus | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Schistosoma mansoni | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | neuropeptide receptor | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Echinococcus multilocularis | G protein coupled receptor 139 | Get druggable targets OG5_127863 | All targets in OG5_127863 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | sex peptide receptor | hypocretin (orexin) receptor 1 | 425 aa | 350 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | heat shock protein 90 | 0.001 | 0.0207 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Echinococcus granulosus | heat shock protein | 0.0012 | 0.0411 | 0.0208 |
Onchocerca volvulus | 0.0035 | 0.2278 | 0.5 | |
Toxoplasma gondii | heat shock protein 90, putative | 0.0012 | 0.0411 | 0.5 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.001 | 0.0207 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.001 | 0.0207 | 0.5 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0012 | 0.0411 | 0.5 |
Echinococcus multilocularis | heat shock protein | 0.0012 | 0.0411 | 0.0208 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0012 | 0.0411 | 0.5 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0012 | 0.0411 | 1 |
Schistosoma mansoni | jun-related protein | 0.0036 | 0.2378 | 0.2051 |
Trichomonas vaginalis | heat shock protein, putative | 0.001 | 0.0207 | 0.4732 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0128 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.001 | 0.0207 | 0.4732 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0012 | 0.0411 | 1 |
Echinococcus granulosus | jun protein | 0.0044 | 0.3062 | 0.2916 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2278 | 0.7041 |
Trichomonas vaginalis | heat shock protein, putative | 0.001 | 0.0207 | 0.4732 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.001 | 0.0207 | 0.5 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.001 | 0.0207 | 0.503 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0012 | 0.0411 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0044 | 0.3062 | 0.2916 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0012 | 0.0411 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0012 | 0.0411 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.0012 | 0.0411 | 0.5 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0012 | 0.0411 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0012 | 0.0411 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0012 | 0.0411 | 0.0208 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2378 | 0.2051 |
Trichomonas vaginalis | heat shock protein, putative | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0044 | 0.3062 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.001 | 0.0207 | 0.5 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Echinococcus multilocularis | neuropeptide receptor | 0.0128 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0012 | 0.0411 | 0.5 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0012 | 0.0411 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.001 | 0.0207 | 0.503 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0044 | 0.3062 | 0.2916 |
Echinococcus multilocularis | jun protein | 0.0044 | 0.3062 | 0.2916 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0012 | 0.0411 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0128 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0012 | 0.0411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2962 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0012 | 0.0411 | 0.5 |
Echinococcus multilocularis | heat shock protein 90 | 0.0012 | 0.0411 | 0.0208 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0012 | 0.0411 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 10 nM | BindingDB_Patents: Radioligand Binding Assay II. For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 receptors, were washed with HEPES (10 mM, pH 7.5), scraped off the culture plates with the same buffer, and centrifuged at 4 C for 5 min at 2500 x g. The cell pellet was either stored at -80 C or used directly. Before the experiments, cell membranes were re-suspended in binding assay buffer (10 mM HEPES, 0.5% (w/v) bovine serum albumin, pH 7.5) by homogenisation with a Polytron homogeniser at 50 Hz for 20 s. In competition experiments, cell homogenates (150µ¿) were incubated in assay buffer (10 mM HEPES, pH 7.5, 0.5 % (w/v) bovine serum albumin, 5 mM MgCI2, 1 mMCaCI2, and tween 0.05%) for 1 h at room temperature with about 1 nM of the radioligand [3H]-SB649868, 66 Ci/mmole, 50 µ¿), and with various concentrations of compounds of the invention (50 µ¿) in triplicates. | ChEMBL. | No reference |
Kd (binding) | = 17 nM | BindingDB_Patents: Radioligand Binding Assay II . For crude cell membrane preparations, cells (CHO, Chinese hamster ovary or HEK, human embryonic kidney) expressing human orexin 1 or human orexin 2 receptors, were washed with HEPES (10 mM, pH 7.5), scraped off the culture plates with the same buffer, and centrifuged at 4 C for 5 min at 2500 x g. The cell pellet was either stored at -80 C or used directly. Before the experiments, cell membranes were re-suspended in binding assay buffer (10 mM HEPES, 0.5% (w/v) bovine serum albumin, pH 7.5) by homogenisation with a Polytron homogeniser at 50 Hz for 20 s. In competition experiments, cell homogenates (150ul) were incubated in assay buffer (10 mM HEPES, pH 7.5, 0.5 % (w/v) bovine serum albumin, 5 mM MgCI2, 1 mMCaCI2, and tween 0.05%) for 1 h at room temperature with about 1 nM of the radioligand [3H]-SB649868, 66 Ci/mmole, 50 ul), and with various concentrations of compounds of the invention (50 ul) in triplicates. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.