Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0263 | 0.471 | 1 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0171 | 0.2979 | 0.2979 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0205 | 0.3624 | 1 |
Brugia malayi | Pax transcription factor protein 2 | 0.0263 | 0.471 | 0.471 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0205 | 0.3624 | 0.3624 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0.0061 | 0.004 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0061 | 0.004 |
Plasmodium vivax | RNA helicase-1, putative | 0.0205 | 0.3624 | 0.5 |
Onchocerca volvulus | 0.0175 | 0.3067 | 0.6511 | |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0205 | 0.3624 | 1 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0014 | 0.0054 | 0.0148 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0546 | 1 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0.0061 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0054 | 0.0054 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0205 | 0.3624 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0047 | 0.0047 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0205 | 0.3624 | 1 |
Echinococcus granulosus | single minded 2 | 0.0041 | 0.0549 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.3624 | 0.3624 |
Echinococcus multilocularis | rho associated protein kinase | 0.0176 | 0.3074 | 0.8482 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0205 | 0.3624 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0205 | 0.3624 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0015 | 0.0061 | 0.004 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0205 | 0.3624 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0047 | 0.0047 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0205 | 0.3624 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0205 | 0.3624 | 1 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0014 | 0.0054 | 0.5 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0014 | 0.0054 | 0.002 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0014 | 0.0054 | 0.0148 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0014 | 0.0054 | 0.002 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0205 | 0.3624 | 1 |
Brugia malayi | PAS domain containing protein | 0.0055 | 0.0817 | 0.0817 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0205 | 0.3624 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0041 | 0.0549 | 0.0549 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0205 | 0.3624 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0205 | 0.3624 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0176 | 0.3074 | 0.8482 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0263 | 0.471 | 0.471 |
Onchocerca volvulus | 0.0176 | 0.3074 | 0.6526 | |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0205 | 0.3624 | 1 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0014 | 0.0054 | 0.0148 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0205 | 0.3624 | 1 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0014 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0047 | 0.0047 |
Brugia malayi | hypoxia-induced factor 1 | 0.0171 | 0.2979 | 0.2979 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0061 | 0.004 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0205 | 0.3624 | 1 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0041 | 0.0549 | 0.1516 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0205 | 0.3624 | 0.5 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0014 | 0.0054 | 0.002 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0047 | 0.0047 |
Onchocerca volvulus | 0.0041 | 0.0549 | 0.1166 | |
Mycobacterium leprae | Possible regulatory protein | 0.0014 | 0.0054 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0205 | 0.3624 | 1 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0176 | 0.3074 | 0.8482 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0014 | 0.0054 | 0.0148 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0205 | 0.3624 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0205 | 0.3624 | 0.5 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0015 | 0.0061 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.3247 | 0.3247 |
Mycobacterium ulcerans | putative regulatory protein | 0.0041 | 0.0549 | 1 |
Brugia malayi | hypothetical protein | 0.0185 | 0.3247 | 0.3247 |
Schistosoma mansoni | single-minded | 0.0055 | 0.0817 | 0.2255 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0205 | 0.3624 | 0.7694 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0047 | 0.0047 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0055 | 0.0817 | 0.2255 |
Onchocerca volvulus | 0.0014 | 0.0054 | 0.0114 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.