Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TTK protein kinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0189 | 0.6678 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0189 | 0.6678 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0189 | 0.6678 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0087 | 0.2972 | 0.2972 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0189 | 0.6678 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0189 | 0.6678 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0189 | 0.6678 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0189 | 0.6678 | 1 |
Loa Loa (eye worm) | TTK protein kinase | 0.0087 | 0.2972 | 0.2972 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0189 | 0.6678 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0189 | 0.6678 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0087 | 0.2972 | 0.4451 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.028 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0087 | 0.2972 | 0.2972 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0087 | 0.2972 | 0.4451 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0189 | 0.6678 | 0.6678 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0189 | 0.6678 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0189 | 0.6678 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0189 | 0.6678 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0189 | 0.6678 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0189 | 0.6678 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.6678 | 0.6678 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0189 | 0.6678 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0189 | 0.6678 | 0.6678 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0189 | 0.6678 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0189 | 0.6678 | 1 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0087 | 0.2972 | 0.4451 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0189 | 0.6678 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0189 | 0.6678 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0189 | 0.6678 | 1 |
Onchocerca volvulus | 0.028 | 1 | 1 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0189 | 0.6678 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 189 nM | BindingDB_Patents: Kinase Assay. The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-ATP, and in the presence of their own optimal buffer and cofactors.At the end of the phosphorylation reaction, more than 98% unlabeled ATP and radioactive ATP is captured by an excess of the ion exchange dowex resin; the resin then settles down to the bottom of the reaction plate by gravity.Supernatant is subsequently withdrawn and transferred into a counting plate, then evaluated by P-counting.Reagents/Assay Conditionsi. Dowex Resin Preparation500 g of wet resin (SIGMA, custom prepared resin DOWEX 1x8 200-400 mesh, 2.5 Kg) are weighed out and diluted to 2 L in 150 mM sodium formate, pH 3.00.The resin is allowed to settle down (some hours) and then the supernatant is discarded. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.