Detailed information for compound 1959668

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 397.468 | Formula: C17H24FN5O3S
  • H donors: 2 H acceptors: 5 LogP: 2.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(nc1)c1noc(n1)N[C@@H]1CC[C@H](CC1)CNS(=O)(=O)C(C)C
  • InChi: 1S/C17H24FN5O3S/c1-11(2)27(24,25)20-9-12-3-6-14(7-4-12)21-17-22-16(23-26-17)15-8-5-13(18)10-19-15/h5,8,10-12,14,20H,3-4,6-7,9H2,1-2H3,(H,21,22,23)/t12-,14-
  • InChiKey: PPIUQPLWFJXMKZ-MQMHXKEQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus neuropeptide Y receptor Y5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus neuropeptide s receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) neuropeptide F receptor 0.0003 0.0031 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0886 0.0886
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus ecdysone induced protein 78C 0.0005 0.0886 0.0886
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0005 0.0886 0.0886
Echinococcus multilocularis neuropeptides capa receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0003 0.0031 0.0031
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi Tachykinin-like peptides receptor 99D 0.0003 0.0031 0.0031
Loa Loa (eye worm) steroid hormone receptor 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Leishmania major eukaryotic initiation factor 4a, putative 0.0031 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0005 0.0886 0.0886
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0031 1 1
Echinococcus granulosus g protein coupled receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0003 0.0031 0.0031
Schistosoma mansoni biogenic amine receptor 0.0003 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Leishmania major eukaryotic initiation factor 4a, putative 0.0031 1 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0003 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0005 0.0886 0.0886
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0003 0.0031 0.0031
Brugia malayi Dopamine receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0005 0.0886 0.0886
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0031 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0005 0.0886 0.0886
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0003 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0003 0.0031 0.0031
Schistosoma mansoni growth hormone secretagogue receptor 0.0003 0.0031 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0005 0.0886 0.0886
Schistosoma mansoni biogenic amine (5HT) receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0005 0.0886 0.0886
Treponema pallidum ATP-dependent RNA helicase 0.0031 1 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0005 0.0886 0.0858
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0003 0.0031 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0005 0.0886 0.0886
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0003 0.0031 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0886 0.0886
Schistosoma mansoni neuropeptide receptor 0.0003 0.0031 0.0031
Schistosoma mansoni neuropeptide f receptor 76f 0.0003 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0003 0.0031 0.0031
Echinococcus granulosus dro:myosuppressin receptor 0.0003 0.0031 0.0031
Schistosoma mansoni steroid hormone receptor ad4bp 0.0005 0.0886 0.0886
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0005 0.0886 0.0886
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0003 0.0031 0.0031
Echinococcus granulosus serotonin receptor 0.0003 0.0031 0.0031
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0031 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis ecdysone induced protein 78C 0.0005 0.0886 0.0886
Echinococcus multilocularis neuropeptides capa receptor 0.0003 0.0031 0.0031
Schistosoma mansoni neuropeptide F-like receptor 0.0003 0.0031 0.0031
Echinococcus granulosus alpha 1A adrenergic receptor 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0005 0.0886 0.0886
Schistosoma mansoni hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0031 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Brugia malayi photoreceptor-specific nuclear receptor 0.0005 0.0886 0.0886
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.0003 0.0031 0.0031
Echinococcus granulosus fmrfamide receptor 0.0003 0.0031 0.0031
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0005 0.0886 0.0886
Loa Loa (eye worm) melatonin receptor type 1A 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0003 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0003 0.0031 0.0031
Echinococcus granulosus peptide allatostatin:somatostatin 0.0003 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0003 0.0031 0.0031
Echinococcus multilocularis fmrfamide receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis neuropeptide receptor 0.0003 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi G protein-coupled receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis somatostatin receptor 0.0003 0.0031 0.0031
Echinococcus granulosus tachykinin peptides receptor 99D 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0005 0.0886 0.0886
Brugia malayi larval opioid receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni alpha-1 adrenergic receptor 0.0003 0.0031 0.0031
Brugia malayi GnHR receptor homolog 0.0003 0.0031 0.0031
Echinococcus multilocularis neuropeptide FF receptor 2 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0003 0.0031 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0005 0.0886 0.0886
Plasmodium vivax RNA helicase-1, putative 0.0031 1 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0003 0.0031 0.0031
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis neuropeptide receptor A26 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0005 0.0886 0.0886
Brugia malayi neuropeptide F receptor 0.0003 0.0031 0.0031
Echinococcus granulosus g protein coupled receptor 0.0003 0.0031 0.0031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0003 0.0031 0.0031
Echinococcus granulosus 7tm_1 domain containing protein 0.0003 0.0031 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis G-protein coupled receptor, putative 0.0003 0.0031 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Brugia malayi Steroid receptor seven-up type 2 0.0005 0.0886 0.0886
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0005 0.0886 0.0886
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0031 1 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0031 1 0.5
Brugia malayi nuclear receptor NHR-88 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0886 0.0886
Brugia malayi ORL1-like opioid receptor 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi G-protein coupled receptor 0.0003 0.0031 0.0031
Brugia malayi putative neuropeptide receptor NPR1 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni opsin-like receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0886 0.0886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0005 0.0886 0.0886
Loa Loa (eye worm) TYRA-2 protein 0.0003 0.0031 0.0031
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0031 1 0.5
Brugia malayi Serotonin receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi sulfakinin receptor protein 0.0003 0.0031 0.0031
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) neuropeptide F receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi RE15519p 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Echinococcus granulosus sex peptide receptor 0.0003 0.0031 0.0031
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0003 0.0031 0.0031
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0003 0.0031 0.0031
Brugia malayi G-protein coupled receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0003 0.0031 0.0031
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0005 0.0886 0.0858
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0003 0.0031 0.0031
Echinococcus multilocularis orexin receptor type 2 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0003 0.0031 0.0031
Echinococcus granulosus g protein coupled receptor 0.0003 0.0031 0.0031
Brugia malayi follicle stimulating hormone receptor 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0003 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Onchocerca volvulus 0.0005 0.0886 0.0858
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0005 0.0886 0.0886
Schistosoma mansoni adenoreceptor 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0886 0.0886
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0003 0.0031 0.0031
Brugia malayi putative neuropeptide receptor 0.0003 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0886 0.0886
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0003 0.0031 0.0031
Brugia malayi G protein-coupled receptor F59B2.13 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Echinococcus granulosus 7TM GPCR rhodopsin 0.0003 0.0031 0.0031
Brugia malayi Dopamine receptor protein 1 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0005 0.0886 0.0886
Schistosoma mansoni biogenic amine (5HT) receptor 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0005 0.0886 0.0886
Brugia malayi steroid hormone receptor 0.0005 0.0886 0.0886
Echinococcus granulosus tm gpcr rhodopsin 0.0003 0.0031 0.0031
Echinococcus multilocularis neuropeptide receptor 0.0003 0.0031 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.0003 0.0031 0.0031
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0031 1 0.5
Echinococcus granulosus FTZ F1 alpha 0.0005 0.0886 0.0886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0005 0.0886 0.0886
Echinococcus multilocularis g protein coupled receptor 0.0003 0.0031 0.0031
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0031 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0005 0.0886 0.0886
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0005 0.0886 0.0886
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0005 0.0886 0.0886
Echinococcus multilocularis dro:myosuppressin receptor 0.0003 0.0031 0.0031
Schistosoma mansoni myosin xvIII 0.0003 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0003 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0003 0.0031 0.0031
Echinococcus multilocularis serotonin receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0003 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni retinoic acid receptor RXR 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni histamine h1 receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus g-protein coupled receptor 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0003 0.0031 0.0031
Schistosoma mansoni opsin-like receptor 0.0003 0.0031 0.0031
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0031 1 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0003 0.0031 0.0031
Schistosoma mansoni RAR-like nuclear receptor 0.0005 0.0886 0.0886
Brugia malayi Melatonin receptor type 1A 0.0003 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0003 0.0031 0.0031
Echinococcus multilocularis fmrfamide receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis g-protein coupled receptor 0.0003 0.0031 0.0031
Echinococcus granulosus eukaryotic initiation factor 4A 0.0031 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0005 0.0886 0.0858
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0003 0.0031 0.0031
Brugia malayi Dopamine receptor protein 2 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis sex peptide receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0886 0.0886
Schistosoma mansoni hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0003 0.0031 0.0031
Brugia malayi AKH receptor 0.0003 0.0031 0.0031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0005 0.0886 0.0886
Echinococcus multilocularis neuropeptide s receptor 0.0003 0.0031 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.0003 0.0031 0.0031
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0031 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0886 0.0886
Schistosoma mansoni opsin-like receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0003 0.0031 0.0031
Plasmodium falciparum eukaryotic initiation factor 4A 0.0031 1 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0003 0.0031 0.0031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0886 0.0886
Schistosoma mansoni coup transcription factor 0.0005 0.0886 0.0886
Echinococcus granulosus neuropeptides capa receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0031 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0003 0.0031 0.0031
Schistosoma mansoni biogenic amine receptor 0.0003 0.0031 0.0031
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0031 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 1 1
Schistosoma mansoni hypothetical protein 0.0003 0.0031 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0005 0.0886 0.0886
Schistosoma mansoni amine GPCR 0.0003 0.0031 0.0031
Schistosoma mansoni biogenic amine receptor 0.0003 0.0031 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0003 0.0031 0.0031
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0003 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0005 0.0886 0.0886
Echinococcus multilocularis allatostatin A receptor 0.0003 0.0031 0.0031
Brugia malayi Serotonin receptor 0.0003 0.0031 0.0031
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0003 0.0031 0.0031
Brugia malayi neuropeptide F receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Loa Loa (eye worm) G-protein coupled receptor 0.0003 0.0031 0.0031
Echinococcus granulosus allatostatin A receptor 0.0003 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0005 0.0886 0.0886
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0005 0.0886 0.0886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0005 0.0886 0.0886
Echinococcus granulosus orexin receptor type 2 0.0003 0.0031 0.0031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0003 0.0031 0.0031
Echinococcus granulosus G protein coupled receptor 139 0.0003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0005 0.0886 0.0886
Echinococcus granulosus somatostatin receptor 0.0003 0.0031 0.0031
Brugia malayi ecdysteroid receptor 0.0005 0.0886 0.0886
Echinococcus multilocularis G protein coupled receptor 139 0.0003 0.0031 0.0031
Echinococcus multilocularis serotonin receptor 0.0003 0.0031 0.0031
Brugia malayi nuclear hormone receptor 0.0005 0.0886 0.0886
Brugia malayi hypothetical protein 0.0003 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0003 0.0031 0.0031
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0031 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0003 0.0031 0.0031

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.8 nM BindingDB_Patents: Binding Assay. cDNA sequence encoding a mouse NPY Y5 receptor (Biochim. Biophys. Acta 1328:83-89, 1997) was cloned in a vector (pME18S, Takebe et al. Mol. Cell. Biol. 8, 8957). The obtained expression vector was transfected into CHO cells as a host by using Lipofect AMINE reagent (Trademark, Gico BRL Co., Ltd.) according to the instruction manual. The cells that stably express NPY Y5 receptor were obtained.The membranes prepared from the CHO cells expressing NPY Y5 receptor, the compound of this invention and 30,000 cpm [125I] peptide YY (60 pM of final concentration: Healthcare) were incubated in the assay buffer (20 mM HEPES-Hanks buffer containing 0.1% bovine serum albumin, pH 7.4) at 25° C. for 2 hours, and then the membrane was filtered from the mixture through a glass filter (GF/C) presoaked with 1% polyethyleneimine. After washing with 50 mM Tris-HCl buffer (pH 7.4), radioactivity retained on the filters was quantified with a gamma counter. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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