Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | No references | |
Homo sapiens | ret proto-oncogene | Starlite/ChEMBL | No references |
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | No references |
Homo sapiens | activin A receptor type II-like 1 | Starlite/ChEMBL | No references |
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | Get druggable targets OG5_157629 | All targets in OG5_157629 |
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.6026 | 0.9739 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0293 | 0.0443 |
Echinococcus multilocularis | activin receptor type | 0.0122 | 0.242 | 0.2387 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0115 | 0.2259 | 0.3606 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0115 | 0.2259 | 0.2225 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.021 | 0.0308 |
Brugia malayi | Protein kinase domain containing protein | 0.0295 | 0.6187 | 1 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0115 | 0.2259 | 0.3606 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0295 | 0.6187 | 1 |
Schistosoma mansoni | ephrin receptor | 0.0013 | 0.0043 | 0.0095 |
Schistosoma mansoni | plexin | 0.0021 | 0.021 | 0.0791 |
Onchocerca volvulus | 0.0021 | 0.021 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase | 0.0295 | 0.6187 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0122 | 0.242 | 0.3891 |
Schistosoma mansoni | protein kinase | 0.0122 | 0.242 | 1 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0295 | 0.6187 | 0.6171 |
Echinococcus granulosus | activin receptor type | 0.0122 | 0.242 | 0.3869 |
Brugia malayi | plexin A | 0.0025 | 0.0293 | 0.0139 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0122 | 0.242 | 0.3697 |
Schistosoma mansoni | protein kinase | 0.0115 | 0.2259 | 0.9328 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.0293 | 0.0251 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.0293 | 0.0407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.334 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
IC50 (binding) | = 9.157 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
IC50 (binding) | = 13.07 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2000 nM | In Vitro Kinase Activity Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.