Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0528 | 0.1167 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.193 | 0.6967 | 0.6882 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0528 | 0.1167 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.2036 | 0.7403 | 0.733 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2036 | 0.7403 | 0.733 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0528 | 0.1167 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0734 | 0.2018 | 0.1794 |
Chlamydia trachomatis | glutamine binding protein | 0.0528 | 0.1167 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.193 | 0.6967 | 0.6882 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2242 | 0.8255 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2664 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0528 | 0.1167 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0528 | 0.1167 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 45.4 nM | Binding affinity against human Corticotropin releasing factor receptor 1 expressed in HEK 293E cells using [125I]-TYR-oCRH | ChEMBL. | 10328310 |
Ki (binding) | = 45.4 nM | Binding affinity against human Corticotropin releasing factor receptor 1 expressed in HEK 293E cells using [125I]-TYR-oCRH | ChEMBL. | 10328310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.