Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | p2X purinoceptor 4 | purinergic receptor P2X, ligand-gated ion channel, 3 | 397 aa | 383 aa | 37.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0148 | 0.1404 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0148 | 0.1404 | 0.1404 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0148 | 0.1404 | 0.1654 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0481 | 0.8484 | 1 |
Schistosoma mansoni | loxhd1 | 0.0148 | 0.1404 | 0.1404 |
Schistosoma mansoni | tyrosinase precursor | 0.0553 | 1 | 1 |
Echinococcus multilocularis | RUN | 0.0148 | 0.1404 | 0.1654 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1404 | 1 |
Onchocerca volvulus | 0.0148 | 0.1404 | 1 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0148 | 0.1404 | 0.1654 |
Schistosoma mansoni | polycystin 1-related | 0.0148 | 0.1404 | 0.1404 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.1404 | 0.1404 |
Schistosoma mansoni | rab6-interacting | 0.0148 | 0.1404 | 0.1404 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0148 | 0.1404 | 0.1654 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0148 | 0.1404 | 0.1654 |
Schistosoma mansoni | lipoxygenase | 0.0215 | 0.2824 | 0.2824 |
Brugia malayi | Doublecortin family protein | 0.0148 | 0.1404 | 1 |
Echinococcus granulosus | RUN | 0.0148 | 0.1404 | 0.1654 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0148 | 0.1404 | 0.1654 |
Onchocerca volvulus | 0.0148 | 0.1404 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1404 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0148 | 0.1404 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0481 | 0.8484 | 0.8484 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0148 | 0.1404 | 0.1654 |
Loa Loa (eye worm) | doublecortin family protein | 0.0148 | 0.1404 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1404 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0481 | 0.8484 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 nM | BindingDB_Patents: Inhibiton Assay. Inhibition assay using human P2X3 receptor gene (GeneBank accession number Y07683). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.