Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.3021 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2547 | 0.8048 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0593 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0593 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0593 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0593 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2316 | 0.7097 | 0.6791 |
Echinococcus granulosus | nmda type glutamate receptor | 0.2316 | 0.7097 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0593 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.2198 | 0.6609 | 0.6252 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0593 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production; Imax=84% | ChEMBL. | 9871731 |
IC50 (binding) | = 0.2 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production; Imax=84% | ChEMBL. | 9871731 |
IC50 (binding) | = 0.57 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production. | ChEMBL. | 9871731 |
IC50 (binding) | = 0.57 uM | Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production. | ChEMBL. | 9871731 |
Inhibition (binding) | = 8 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 8 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 10 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 10 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 17 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 17 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 24 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 24 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 37 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 37 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 0.1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 54 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 54 % | Inhibitory activity against cyclooxygenase-2 (COX-2) in cell assay using stably transfected Cos-A2 CELLS at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 54 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 54 % | Inhibitory activity against cyclooxygenase-2 (COX-2) in cell assay using stably transfected Cos-A2 CELLS at dose 1 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 57 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 57 % | Inhibitory activity against Prostaglandin G/H synthase 1 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 75 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 75 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 1 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 76 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 10 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 76 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 Cells at dose 10 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 80 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 80 % | Inhibitory activity against Prostaglandin G/H synthase 2 in Microsomal assay at dose 10 microg/ml | ChEMBL. | 9871731 |
Inhibition (binding) | = 90 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 10 ug/mL | ChEMBL. | 9871731 |
Inhibition (binding) | = 90 % | Inhibitory activity against Prostaglandin G/H synthase 2 in cell assay using stably transfected Cos-A2 CELLS at dose 10 ug/mL | ChEMBL. | 9871731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.