Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta tubulin | 0.0807 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0807 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0807 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0807 | 1 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0807 | 1 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0355 | 0 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0807 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0355 | 0 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0807 | 1 | 1 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Loa Loa (eye worm) | tubulin beta chain | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Schistosoma mansoni | tubulin subunit beta | 0.0807 | 1 | 1 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0807 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Echinococcus granulosus | beta tubulin | 0.0807 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0807 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0807 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0807 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0807 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0807 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0807 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0807 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0807 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0807 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0807 | 1 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0807 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0807 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0807 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0807 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Giardia lamblia | Beta tubulin | 0.0807 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0807 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0807 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0807 | 1 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0807 | 1 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0807 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0807 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0807 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0807 | 1 | 1 |
Onchocerca volvulus | 0.0355 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | BindingDB_Patents: Enzyme Assay-Time Dependence. Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.