TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 568.669 | Formula: C31H36N8O3
H donors: 2 H acceptors: 5 LogP: 3.72 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCc1nn(c2c1c(ccc2)NC(=O)c1cnc2n1ccc(c2)OCCN1CC[N+](CC1)([O-])C)Cc1cccc(n1)C
InChi: 1S/C31H36N8O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)21-23-8-5-7-22(2)33-23)34-31(40)28-20-32-29-19-24(11-12-37(28)29)42-18-15-36-13-16-39(3,41)17-14-36/h5-12,19-20H,4,13-18,21H2,1-3H3,(H,34,40)
InChiKey: ORWFYKVVNFEZBW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	colony stimulating factor 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptides capa receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0022	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus granulosus	defective proboscis extension response	0.0014	0.0043	0.0043
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0058	0.0279	0.0278
Brugia malayi	larval opioid receptor	0.0058	0.0279	0.0278
Schistosoma mansoni	protein kinase	0.0008	0.0011	0.0011
Schistosoma mansoni	cell adhesion molecule	0.0019	0.0068	0.0068
Brugia malayi	G-protein coupled receptor	0.0058	0.0279	0.0278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	7tm_1 domain containing protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	g protein coupled receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	neuropeptide Y receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	sex peptide receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0058	0.0279	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.0058	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0058	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0058	0.0279	0.0279
Echinococcus multilocularis	g protein coupled receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	Immunoglobulin	0.0014	0.0043	0.0043
Echinococcus granulosus	g protein coupled receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	growth hormone secretagogue receptor	0.0058	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 2	0.0058	0.0279	0.0278
Echinococcus granulosus	neuropeptides capa receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	fmrfamide receptor	0.0058	0.0279	0.0279
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0008	0.0011	0.5
Echinococcus granulosus	roundabout 2	0.0019	0.0068	0.0068
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0008	0.0011	0.5
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.1855	1	1
Brugia malayi	G protein-coupled receptor	0.0058	0.0279	0.0278
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0058	0.0279	0.0279
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.1855	1	1
Schistosoma mansoni	opsin-like receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus granulosus	neuropeptide receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	fmrfamide receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0019	0.0068	0.0068
Echinococcus granulosus	tm gpcr rhodopsin	0.0848	0.4555	0.4555
Leishmania major	protein kinase, putative	0.0008	0.0011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Echinococcus granulosus	dro:myosuppressin receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0058	0.0279	0.0279
Schistosoma mansoni	neuropeptide f receptor 76f	0.0058	0.0279	0.0279
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0014	0.0043	0.0043
Loa Loa (eye worm)	G-protein coupled receptor	0.0058	0.0279	0.0279
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0058	0.0279	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	roundabout 2	0.0019	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0043
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0058	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	neuropeptide F-like receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	hypothetical protein	0.0899	0.483	0.483
Brugia malayi	Serotonin receptor	0.0058	0.0279	0.0278
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	g protein coupled receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0058	0.0279	0.0279
Echinococcus granulosus	neuropeptide Y receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	histamine h1 receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0058	0.0279	0.0279
Schistosoma mansoni	opsin-like receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0043
Schistosoma mansoni	neuropeptide F-like receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0058	0.0279	0.0279
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0008	0.0011	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0058	0.0279	0.0278
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Plasmodium falciparum	protein kinase, putative	0.0008	0.0011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Schistosoma mansoni	transient receptor potential channel	0.0006	0.0001	0.0001
Echinococcus granulosus	somatostatin receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	orexin receptor type 2	0.0058	0.0279	0.0279
Loa Loa (eye worm)	TYRA-2 protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0058	0.0279	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus multilocularis	allatostatin A receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	fmrfamide receptor	0.0058	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0014	0.0043	0.0043
Brugia malayi	Fibronectin type III domain containing protein	0.0014	0.0043	0.0043
Echinococcus granulosus	neuropeptides capa receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0058	0.0279	0.0279
Schistosoma mansoni	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	opsin-like receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0008	0.0011	0.0011
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0058	0.0279	0.0279
Echinococcus multilocularis	serotonin receptor	0.0206	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0058	0.0279	0.0278
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	transient receptor potential cation channel	0.0006	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Echinococcus granulosus	orexin receptor type 2	0.0058	0.0279	0.0279
Brugia malayi	Dopamine receptor protein 1	0.0058	0.0279	0.0278
Echinococcus multilocularis	calcium activated potassium channel	0.0011	0.0026	0.0026
Brugia malayi	neuropeptide F receptor	0.0058	0.0279	0.0278
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0058	0.0279	0.0278
Schistosoma mansoni	vesicular amine transporter	0.002	0.0076	0.0076
Schistosoma mansoni	myosin xvIII	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	neuropeptides capa receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	Melatonin receptor type 1A	0.0058	0.0279	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Brugia malayi	G-protein coupled receptor	0.0058	0.0279	0.0278
Echinococcus granulosus	sex peptide receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0503	0.2689	0.2689
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0008	0.0011	0.0011
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0058	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Brugia malayi	putative neuropeptide receptor NPR1	0.0058	0.0279	0.0278
Onchocerca volvulus		0.0058	0.0279	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	tyrosine kinase	0.0008	0.001	0.001
Onchocerca volvulus		0.0058	0.0279	0.5
Echinococcus multilocularis	somatostatin receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0058	0.0279	0.0279
Schistosoma mansoni	neuropeptide receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	GnHR receptor homolog	0.0058	0.0279	0.0278
Echinococcus granulosus	G protein coupled receptor 139	0.0058	0.0279	0.0279
Schistosoma mansoni	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	neuropeptide F receptor	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0206	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0008	0.0011	0.0011
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Schistosoma mansoni	biogenic amine receptor	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus granulosus	biogenic amine 5HT receptor	0.0058	0.0279	0.0279
Brugia malayi	sulfakinin receptor protein	0.0058	0.0279	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0068	0.0068
Schistosoma mansoni	biogenic amine receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0014	0.0043	0.0043
Onchocerca volvulus		0.0058	0.0279	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0008	0.0011	0.5
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.1855	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	neuropeptide Y receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.0058	0.0279	0.0279
Brugia malayi	G protein-coupled receptor F59B2.13	0.0058	0.0279	0.0278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	neuropeptide receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0068	0.0068
Schistosoma mansoni	adenoreceptor	0.0058	0.0279	0.0279
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	neuropeptide F receptor	0.0058	0.0279	0.0278
Echinococcus granulosus	short transient receptor potential channel 6	0.0006	0.0001	0.0001
Echinococcus granulosus	twitchin	0.0019	0.0069	0.0069
Loa Loa (eye worm)	melatonin receptor type 1A	0.0058	0.0279	0.0279
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	activin receptor type	0.0008	0.0011	0.0011
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0058	0.0279	0.0279
Echinococcus multilocularis	Immunoglobulin	0.0014	0.0043	0.0043
Schistosoma mansoni	nephrin	0.0014	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0043
Brugia malayi	Dopamine receptor	0.0058	0.0279	0.0278
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	neuropeptide F receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	7TM GPCR rhodopsin	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0043
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0058	0.0279	0.0279
Loa Loa (eye worm)	G-protein coupled receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0058	0.0279	0.0279
Echinococcus multilocularis	g-protein coupled receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	protein kinase	0.0008	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0058	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0058	0.0279	0.0279
Echinococcus multilocularis	G protein coupled receptor 139	0.0058	0.0279	0.0279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0848	0.4555	0.4555
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	neuropeptide FF receptor 2	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	neuropeptide receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Brugia malayi	RE15519p	0.0058	0.0279	0.0278
Echinococcus granulosus	g-protein coupled receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	conserved hypothetical protein	0.0842	0.4519	0.4519
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	neuroglian	0.0014	0.0043	0.0043
Echinococcus granulosus	neuroglian	0.0014	0.0043	0.0043
Onchocerca volvulus		0.0058	0.0279	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Entamoeba histolytica	protein kinase domain containing protein	0.0008	0.0011	0.5
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0058	0.0279	0.0278
Echinococcus multilocularis	neuropeptide receptor A26	0.0058	0.0279	0.0279
Brugia malayi	hypothetical protein	0.0058	0.0279	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0043	0.0043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	calcium activated potassium channel	0.0011	0.0026	0.0026
Echinococcus granulosus	neuropeptide receptor	0.0058	0.0279	0.0279
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0058	0.0279	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0058	0.0279	0.0278
Brugia malayi	ORL1-like opioid receptor	0.0058	0.0279	0.0278
Echinococcus granulosus	activin receptor type	0.0008	0.0011	0.0011
Trypanosoma brucei	protein kinase, putative	0.0008	0.0011	0.5
Echinococcus granulosus	g protein coupled receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1082	0.1082
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0009	0.0018	0.0018
Echinococcus granulosus	serotonin receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0058	0.0279	0.0279
Echinococcus multilocularis	neuropeptide Y receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	serine/threonine protein kinase	0.1855	1	1
Echinococcus multilocularis	Immunoglobulin	0.0014	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0068	0.0068
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	neuropeptide receptor A26	0.0058	0.0279	0.0279
Schistosoma mansoni	biogenic amine receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	dro:myosuppressin receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0058	0.0279	0.0279
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0058	0.0279	0.0279
Echinococcus granulosus	neuropeptide s receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	short transient receptor potential channel 6	0.0006	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Onchocerca volvulus		0.0058	0.0279	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0001	0.0001
Echinococcus granulosus	transient receptor potential cation channel	0.0006	0.0001	0.0001
Echinococcus multilocularis	neuropeptide s receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0206	0.1082	0.1082
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0058	0.0279	0.0279
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Schistosoma mansoni	amine GPCR	0.0058	0.0279	0.0279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0058	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0058	0.0279	0.0279
Brugia malayi	putative neuropeptide receptor	0.0058	0.0279	0.0278
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0058	0.0279	0.0279
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0086	0.0085
Schistosoma mansoni	hypothetical protein	0.0051	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0279	0.0279
Brugia malayi	AKH receptor	0.0058	0.0279	0.0278
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0058	0.0279	0.0279
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0058	0.0279	0.0279
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0058	0.0279	0.0279
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0014	0.0043	0.0043
Echinococcus multilocularis	serotonin receptor	0.0206	0.1082	0.1082
Brugia malayi	Serotonin receptor	0.0619	0.3313	0.3313
Echinococcus granulosus	allatostatin A receptor	0.0058	0.0279	0.0279
Echinococcus multilocularis	transient receptor potential cation channel	0.0006	0.0001	0.0001
Schistosoma mansoni	protein kinase	0.0008	0.0011	0.0011

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 725.3 nM	BindingDB_Patents: LANCE Ultra TR-FRET Assay. The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ultra TR-FRET assay technology from PerkinElmer (Waltham, Mass.). Incubation mixtures contained the following: 50 mM NaHEPES, pH 7.3, 10 mM MgCl2, 0.5 mM MnCl2, 0.01% Triton X-100, 1 mM DTT, 1% DMSO, 10 uM ATP, 25 nM LANCE Ultra ULight-poly GAT and 0.5 nM cFMS in a total volume of 10 uL. The concentration of compounds of Formula I was varied over 10-point, 3-fold dilution series with 10,000 nM typically being the highest dose. Incubations were carried out in white ProxyPlate-384 Plus plates (PerkinElmer) at 22 C. for 20 minutes, after which 10 uL of a quench/detection solution was added containing 1x LANCE Detection Buffer, 2 nM LANCE EuW1024 Anti-phosphotyrosine (PY20) and 36 mM EDTA. After an additional 60 minutes incubation at 22 C., the assay plate was read on an EnVision 2103 Multilabel Reader (PerkinElmer).	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3642093

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1982502