Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 358 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0092 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0092 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0092 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0092 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0092 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0092 | 0.5 | 0.5 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0092 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0092 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0092 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0092 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0092 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50.09 nM | BindingDB_Patents: IMAP Assay. Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 µl of 25× compound was added to 140 of kinase buffer containing 0.25 ng fully phosphorylated, active Mouse ERK2 protein. Following a 30 minute incubation, the reactions were initiated by addition of 10 µl of kinase buffer containing 1 µM ERK2 IMAP substrate peptide (0.9 µM unlabeled IPTTPITTTYFFFK-CONH2 and 100 nM IPTTPITTTYFFFK(5-carboxyfluorescein)-CONH2) and 30 µM ATP. Reactions proceeded for 30 minutes before termination by addition of 60 µl IMAP detection beads in binding buffer. Plates were read as above after 30 minute binding equilibration. Active compounds were reconfirmed in an independent assay. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.