Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 8 (sodium/calcium exchanger), member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0035 | 0.2212 | 0.2212 |
Echinococcus granulosus | histone deacetylase 8 | 0.0035 | 0.2212 | 0.2212 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0035 | 0.2199 | 0.2199 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0035 | 0.2212 | 0.2212 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0122 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0035 | 0.2199 | 0.2199 |
Entamoeba histolytica | histone deacetylase, putative | 0.0122 | 1 | 0.5 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0091 | 0.7219 | 0.7219 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0035 | 0.2212 | 0.2212 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0122 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0122 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0035 | 0.2212 | 0.2212 |
Brugia malayi | Histone deacetylase 1 | 0.0122 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0035 | 0.2212 | 0.2212 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0122 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0122 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.179 | 0.179 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2212 | 0.2212 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0122 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0035 | 0.2212 | 0.2212 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0035 | 0.2212 | 0.2212 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.235 | 0.235 |
Leishmania major | histone deacetylase, putative | 0.0122 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0122 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0035 | 0.2212 | 0.2212 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.1995 | 0.1543 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0122 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0122 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0035 | 0.2212 | 0.2212 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0035 | 0.2212 | 0.2212 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0035 | 0.2212 | 0.2212 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0122 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0035 | 0.2212 | 0.2212 |
Echinococcus granulosus | histone deacetylase 6 | 0.0035 | 0.2212 | 0.2212 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0035 | 0.2212 | 0.2212 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0091 | 0.7219 | 0.7219 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0038 | 0.2483 | 0.2483 |
Plasmodium falciparum | histone deacetylase 1 | 0.0122 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0035 | 0.2212 | 0.2212 |
Echinococcus granulosus | histone deacetylase | 0.0035 | 0.2212 | 0.2212 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0122 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0122 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0122 | 1 | 1 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0091 | 0.7219 | 0.7219 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0036 | 0.235 | 0.235 |
Schistosoma mansoni | histone deacetylase | 0.0122 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0035 | 0.2212 | 0.2212 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0035 | 0.2199 | 0.2199 |
Echinococcus granulosus | histone deacetylase 7 | 0.0035 | 0.2212 | 0.2212 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0038 | 0.2483 | 0.2483 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0122 | 1 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0122 | 1 | 1 |
Echinococcus granulosus | sodium calcium exchanger | 0.0091 | 0.7219 | 0.7219 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0035 | 0.2199 | 0.2199 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0122 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0035 | 0.2212 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0035 | 0.2212 | 0.2212 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0122 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0122 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0122 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0122 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0035 | 0.2212 | 0.2212 |
Echinococcus granulosus | histone deacetylase 6 | 0.0035 | 0.2212 | 0.2212 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0032 | 0.1995 | 0.1543 |
Trypanosoma brucei | histone deacetylase 1 | 0.0122 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0035 | 0.2212 | 0.2212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | BindingDB_Patents: Reverse Mode Assay. The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loaded with the dye by means of the acetoxymethyl ester Fluo-4 AM (Invitrogen, F14202), which is cleaved intracellularly by esterase activity to yield the charged species of free Fluo-4. After an preincubation period with the test compound, Gramicidine (Sigma, G5002) was added. Gramicidine is an ionophor for Na+ions mediating an increase of intracellular Na+ions. Consequently, intracellular Na+ions are exchanged against extracellular Ca2+ions (Ca2+influx, reverse mode). The intracellular elevation of Ca2+ ions was detected by measuring the fluorescence of Fluo-4 at a wavelength of 520 nm by a FLIPR device.Briefly, for the reverse mode transport assay 18000 cells per well were seeded into a 96 well microplate (Corning COSTAR 3904) and incubated overnight in culture medium (1x Nut Mix F12 (Ham) (Gibco, 21765-029); 10% (v/v) fetal calf serum. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.