Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 8 (sodium/calcium exchanger), member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/calcium exchanger | 0.0091 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0021 | 0.1102 | 0.1102 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0074 | 0.7812 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0021 | 0.1102 | 0.1411 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0074 | 0.7812 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0074 | 0.7812 | 0.7812 |
Schistosoma mansoni | histone deacetylase | 0.0074 | 0.7812 | 0.7812 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0021 | 0.1102 | 0.1102 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0021 | 0.1102 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0074 | 0.7812 | 0.7812 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.3506 | 0.4138 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0021 | 0.1102 | 0.1102 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | histone deacetylase 6 | 0.0021 | 0.1102 | 0.1102 |
Giardia lamblia | Histone deacetylase | 0.0074 | 0.7812 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.3864 | 0.3864 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus multilocularis | histone deacetylase | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | histone deacetylase 6 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | histone deacetylase 8 | 0.0021 | 0.1102 | 0.1102 |
Entamoeba histolytica | histone deacetylase, putative | 0.0074 | 0.7812 | 0.5 |
Brugia malayi | Histone deacetylase family protein | 0.0021 | 0.1102 | 0.1411 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0021 | 0.1102 | 0.1102 |
Trypanosoma brucei | histone deacetylase 1 | 0.0074 | 0.7812 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.4363 | 0.4363 |
Plasmodium falciparum | histone deacetylase 1 | 0.0074 | 0.7812 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.3864 | 0.3864 |
Brugia malayi | histone deacetylase 11 | 0.0021 | 0.1102 | 0.1411 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.3055 | 0.3055 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0074 | 0.7812 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0074 | 0.7812 | 0.7812 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0036 | 0.3055 | 0.391 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0021 | 0.1102 | 0.1102 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.3506 | 0.4138 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.1102 | 0.1102 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0074 | 0.7812 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0074 | 0.7812 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.4363 | 0.4363 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0021 | 0.1102 | 0.1102 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0021 | 0.1102 | 0.1102 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3145 | 0.3145 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0074 | 0.7812 | 1 |
Leishmania major | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0074 | 0.7812 | 0.7812 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0074 | 0.7812 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.3864 | 0.3864 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0074 | 0.7812 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | histone deacetylase | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | histone deacetylase 6 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus granulosus | histone deacetylase 1 | 0.0074 | 0.7812 | 0.7812 |
Leishmania major | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0074 | 0.7812 | 0.7812 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0021 | 0.1102 | 0.1102 |
Brugia malayi | Histone deacetylase 1 | 0.0074 | 0.7812 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0074 | 0.7812 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0074 | 0.7812 | 0.7812 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.7812 | 0.7812 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0021 | 0.1102 | 0.1102 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0091 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.3864 | 0.4946 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0021 | 0.1102 | 0.1102 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | BindingDB_Patents: Reverse Mode Assay. The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loaded with the dye by means of the acetoxymethyl ester Fluo-4 AM (Invitrogen, F14202), which is cleaved intracellularly by esterase activity to yield the charged species of free Fluo-4. After an preincubation period with the test compound, Gramicidine (Sigma, G5002) was added. Gramicidine is an ionophor for Na+ions mediating an increase of intracellular Na+ions. Consequently, intracellular Na+ions are exchanged against extracellular Ca2+ions (Ca2+influx, reverse mode). The intracellular elevation of Ca2+ ions was detected by measuring the fluorescence of Fluo-4 at a wavelength of 520 nm by a FLIPR device.Briefly, for the reverse mode transport assay 18000 cells per well were seeded into a 96 well microplate (Corning COSTAR 3904) and incubated overnight in culture medium (1x Nut Mix F12 (Ham) (Gibco, 21765-029); 10% (v/v) fetal calf serum. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.