Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 8 (sodium/calcium exchanger), member 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | G-protein coupled receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | larval opioid receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0036 | 0.0115 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0066 | 0.2044 | 0.2044 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | neuropeptide F receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Serotonin receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Dopamine receptor protein 1 | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | solute carrier family 8 | 0.0091 | 0.3688 | 0.3688 |
Loa Loa (eye worm) | glutamate receptor | 0.0135 | 0.6579 | 0.6579 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0188 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0066 | 0.2044 | 0.1986 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0167 | 0.8623 | 0.8613 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | ORL1-like opioid receptor | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0036 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0113 | 0.5143 | 0.5108 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | follicle stimulating hormone receptor | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Melatonin receptor type 1A | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | GnHR receptor homolog | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | sulfakinin receptor protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0115 | 0.0115 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Echinococcus granulosus | sodium calcium exchanger | 0.0091 | 0.3688 | 0.3642 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.8623 | 0.8623 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | AKH receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0113 | 0.5143 | 0.5108 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0123 | 0.5747 | 0.5747 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0113 | 0.5143 | 0.5108 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | G-protein coupled receptor | 0.0036 | 0.0073 | 0.0073 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0154 | 0.7791 | 0.7775 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0036 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0091 | 0.3688 | 0.3642 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | putative neuropeptide receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Serotonin receptor | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0135 | 0.6579 | 0.6579 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | RE15519p | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0188 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0167 | 0.8623 | 0.8613 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | neuropeptide F receptor | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Dopamine receptor protein 2 | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | Dopamine receptor | 0.0036 | 0.0073 | 0.0073 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0188 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0091 | 0.3688 | 0.3642 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0036 | 0.0073 | 0.0073 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | G protein-coupled receptor | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0036 | 0.0073 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | glutamate receptor | 0.0053 | 0.1212 | 0.1212 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0073 | 0.0073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 400 nM | BindingDB_Patents: Reverse Mode Assay. The assay is based on the monitoring of intracellular Ca2+concentrations using the calcium-sensitive dye Fluo-4. CHO cells expressing NCX1 were loaded with the dye by means of the acetoxymethyl ester Fluo-4 AM (Invitrogen, F14202), which is cleaved intracellularly by esterase activity to yield the charged species of free Fluo-4. After an preincubation period with the test compound, Gramicidine (Sigma, G5002) was added. Gramicidine is an ionophor for Na+ions mediating an increase of intracellular Na+ions. Consequently, intracellular Na+ions are exchanged against extracellular Ca2+ions (Ca2+influx, reverse mode). The intracellular elevation of Ca2+ ions was detected by measuring the fluorescence of Fluo-4 at a wavelength of 520 nm by a FLIPR device.Briefly, for the reverse mode transport assay 18000 cells per well were seeded into a 96 well microplate (Corning COSTAR 3904) and incubated overnight in culture medium (1x Nut Mix F12 (Ham) (Gibco, 21765-029); 10% (v/v) fetal calf serum. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.