Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein tyrosine kinase 2 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 3 | Starlite/ChEMBL | No references |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Echinococcus multilocularis | protein tyrosine kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma japonicum | Protein tyrosine kinase 2 beta, putative | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Echinococcus granulosus | protein tyrosine kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Loa Loa (eye worm) | TK/FAK protein kinase | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Schistosoma japonicum | expressed protein | Get druggable targets OG5_130513 | All targets in OG5_130513 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.022 | 0.1279 | 0.1279 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.022 | 0.1279 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.022 | 0.1279 | 1 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0313 | 0.281 | 0.3222 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.022 | 0.1279 | 0.1279 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.022 | 0.1279 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.022 | 0.1279 | 0.1279 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.022 | 0.1279 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.022 | 0.1279 | 0.5 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0309 | 0.275 | 0.275 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.022 | 0.1279 | 0.4651 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.022 | 0.1279 | 0.1279 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0606 | 0.7641 | 0.8762 |
Echinococcus granulosus | protein tyrosine kinase | 0.0309 | 0.275 | 0.1687 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.022 | 0.1279 | 0.5 |
Loa Loa (eye worm) | aminopeptidase N | 0.022 | 0.1279 | 0.1467 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.022 | 0.1279 | 0.5 |
Onchocerca volvulus | 0.0749 | 1 | 1 | |
Echinococcus multilocularis | aminopeptidase N | 0.0749 | 1 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.022 | 0.1279 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.022 | 0.1279 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.022 | 0.1279 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.022 | 0.1279 | 0.4651 |
Brugia malayi | Protein kinase domain containing protein | 0.0313 | 0.281 | 0.1755 |
Echinococcus granulosus | aminopeptidase N | 0.0749 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.8721 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0528 | 0.6362 | 0.7295 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.022 | 0.1279 | 0.1279 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.022 | 0.1279 | 0.1279 |
Schistosoma mansoni | tyrosine kinase | 0.0309 | 0.275 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.022 | 0.1279 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.022 | 0.1279 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.3 nM | In Vitro Enzyme Assay | BINDINGDB. | No reference |
IC50 (binding) | = 89.4 nM | BindingDB_Patents: In Vitro Enzyme Assay. The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) assay system. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.