Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | choline kinase | 0.0017 | 0.0307 | 0.5832 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0017 | 0.0307 | 0.5 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0017 | 0.0307 | 0.5 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.0757 | 0.0464 |
Trypanosoma brucei | choline kinase | 0.0017 | 0.0307 | 0.5 |
Brugia malayi | plexin A | 0.0025 | 0.0757 | 0.0464 |
Schistosoma mansoni | plexin | 0.0021 | 0.0526 | 1 |
Trypanosoma cruzi | choline kinase | 0.0017 | 0.0307 | 0.5 |
Giardia lamblia | Ethanolamine kinase, putative | 0.0017 | 0.0307 | 0.5 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0178 | 1 | 1 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0178 | 1 | 1 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0178 | 1 | 1 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0017 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0757 | 0.0757 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0017 | 0.0307 | 0.5832 |
Loa Loa (eye worm) | choline Kinase A | 0.0017 | 0.0307 | 0.0307 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0017 | 0.0307 | 0.5 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0017 | 0.0307 | 0.5832 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0178 | 1 | 1 |
Plasmodium falciparum | choline kinase | 0.0178 | 1 | 1 |
Onchocerca volvulus | 0.0021 | 0.0526 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0307 | 0.0307 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0017 | 0.0307 | 0.5 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0017 | 0.0307 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0021 | 0.0526 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0526 | 0.0526 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.0757 | 0.0464 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0017 | 0.0307 | 0.5 |
Plasmodium vivax | choline kinase, putative | 0.0178 | 1 | 1 |
Leishmania major | choline kinase | 0.0017 | 0.0307 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 21 nM | BindingDB_Patents: Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay. The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) using lanthanide chelates to measure interactions between various binding partners. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.