Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0013 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.069 | 0.069 |
Trichomonas vaginalis | choline/ethanolamine kinase, putative | 0.0013 | 0.01 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0021 | 0.069 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.01 | 0.01 |
Plasmodium vivax | choline kinase, putative | 0.0138 | 1 | 1 |
Leishmania major | choline kinase | 0.0013 | 0.01 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.0993 | 0.0901 |
Entamoeba histolytica | choline/ethanolamine kinase, putative | 0.0013 | 0.01 | 0.5 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0013 | 0.01 | 0.1452 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0138 | 1 | 1 |
Schistosoma mansoni | choline/ethanolamine kinase | 0.0013 | 0.01 | 0.1452 |
Trypanosoma cruzi | choline ethanolamine kinase, putative | 0.0013 | 0.01 | 0.5 |
Loa Loa (eye worm) | choline Kinase A | 0.0013 | 0.01 | 0.01 |
Plasmodium falciparum | choline kinase | 0.0138 | 1 | 1 |
Onchocerca volvulus | 0.0021 | 0.069 | 1 | |
Giardia lamblia | Ethanolamine kinase, putative | 0.0013 | 0.01 | 0.5 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0013 | 0.01 | 0.01 |
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0993 | 0.0993 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0138 | 1 | 1 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0138 | 1 | 1 |
Leishmania major | choline/ethanolamine kinase, putative | 0.0013 | 0.01 | 0.5 |
Trypanosoma brucei | choline/ethanolamine kinase | 0.0013 | 0.01 | 0.5 |
Schistosoma mansoni | choline kinase | 0.0013 | 0.01 | 0.1452 |
Trypanosoma brucei | choline kinase | 0.0013 | 0.01 | 0.5 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.0993 | 0.0901 |
Trypanosoma cruzi | choline kinase | 0.0013 | 0.01 | 0.5 |
Schistosoma mansoni | plexin | 0.0021 | 0.069 | 1 |
Brugia malayi | plexin A | 0.0025 | 0.0993 | 0.0901 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | BindingDB_Patents: Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay. The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) using lanthanide chelates to measure interactions between various binding partners. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.