Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rho-associated, coiled-coil containing protein kinase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0369 | 0.0926 | 0.1594 |
Schistosoma mansoni | hypothetical protein | 0.0523 | 0.2364 | 0.8496 |
Schistosoma mansoni | dihydroceramide desaturase | 0.0568 | 0.2783 | 1 |
Brugia malayi | Disintegrin family protein | 0.0568 | 0.2783 | 0.4793 |
Brugia malayi | Hemopexin family protein | 0.0523 | 0.2364 | 0.4072 |
Brugia malayi | Matrixin family protein | 0.0369 | 0.0926 | 0.1594 |
Mycobacterium ulcerans | hydrolase | 0.0449 | 0.1676 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0466 | 0.1835 | 0.6595 |
Loa Loa (eye worm) | matrixin family protein | 0.0818 | 0.5119 | 0.859 |
Onchocerca volvulus | Matrilysin homolog | 0.0818 | 0.5119 | 1 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.0568 | 0.2783 | 0.2783 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0449 | 0.1676 | 0.2886 |
Brugia malayi | Matrixin family protein | 0.0892 | 0.5807 | 1 |
Brugia malayi | Matrixin family protein | 0.0369 | 0.0926 | 0.1594 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0546 | 0.2579 | 0.3386 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1342 | 1 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0369 | 0.0926 | 0.3326 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0449 | 0.1676 | 0.5 |
Loa Loa (eye worm) | disintegrin family protein | 0.0413 | 0.134 | 0.0848 |
Loa Loa (eye worm) | matrixin family protein | 0.0892 | 0.5807 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0378 | 0.1011 | 0.1011 |
Loa Loa (eye worm) | hypothetical protein | 0.0378 | 0.1011 | 0.0174 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.0568 | 0.2783 | 0.2783 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.1676 | 0.1537 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0818 | 0.5119 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0449 | 0.1676 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0378 | 0.1011 | 0.1011 |
Onchocerca volvulus | 0.0523 | 0.2364 | 0.3431 | |
Brugia malayi | Protein kinase domain containing protein | 0.0546 | 0.2579 | 0.4441 |
Brugia malayi | Matrixin family protein | 0.0369 | 0.0926 | 0.1594 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6050 nM | BindingDB_Patents: Kinase Inhibition Assay. Inhibition of ROCK2 activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073). ROCK2 kinase (UpstateChemicon #14-451) and Flourescein tagged substrate peptide Fl-AKRRRLSSLRA (Molecular Devices product number R7184). | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.