Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | valosin containing protein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cell division protein CDC48CY | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.4584 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0032 | 0.9326 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.002 | 0.4742 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0032 | 0.9326 | 0.9122 |
Brugia malayi | vesicle-fusing ATPase | 0.002 | 0.4584 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0032 | 0.9326 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0034 | 1 | 0.5 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0034 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.002 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0034 | 1 | 1 |
Toxoplasma gondii | cell division protein CDC48AP | 0.002 | 0.4742 | 0.0000097958 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0032 | 0.9326 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0032 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0034 | 1 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.002 | 0.4742 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0032 | 0.9326 | 0.5 |
Trypanosoma brucei | Valosin-containing protein | 0.0032 | 0.9326 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0032 | 0.9326 | 0.5 |
Giardia lamblia | AAA family ATPase | 0.002 | 0.4742 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.002 | 0.4584 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 2000 nM | BindingDB_Patents: ADP Glo Assay. The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds are mixed in buffer (50 mM TRIS pH 7.5, 20 mM MgCl2, 0.02% TX-100, 1 mM DTT, 0.2% (v/v) glycerol) and incubated at 37 C. for 15 minutes. The reaction is terminated and the level of product generated is measured using the ADP Glo Assay Kit (Promega, Madison Wis.). | ChEMBL. | No reference |
IC50 (binding) | < 2000 nM | BindingDB_Patents: ADP Glo Assay. The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds are mixed in buffer (50 mM TRIS pH 7.5, 20 mM MgCl2, 0.02% TX-100, 1 mM DTT, 0.2% (v/v) glycerol) and incubated at 37 C. for 15 minutes. The reaction is terminated and the level of product generated is measured using the ADP Glo Assay Kit (Promega, Madison Wis.). | ChEMBL. | No reference |
IC50 (binding) | = 0.227 uM | Inhibition of human p97 ATPase incubated for 15 mins by ADP Glo luminescence assay | ChEMBL. | 26565666 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.