Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1876 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0 | 0.5 |
Leishmania major | stearic acid desaturase, putative | 0.1876 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | 0.1876 | 1 | 1 | |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1876 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1876 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0009 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1876 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.1876 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1876 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1876 | 1 | 0.5 |
Onchocerca volvulus | 0.1876 | 1 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1876 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 108 nM | Agonist activity at human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Efficacy (functional) | = 24 % | Agonist activity at human androgen receptor expressed in CV1 cells relative to DHT | ChEMBL. | 17257838 |
Efficacy (functional) | = 39 % | Antagonist activity at human androgen receptor expressed in CV1 cells assessed as inhibition of DHT-induced response | ChEMBL. | 17257838 |
IC50 (functional) | = 18 nM | Antagonist activity at human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Ki (binding) | = 16 nM | Binding affinity to human androgen receptor expressed in CV1 cells | ChEMBL. | 17257838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.