Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0452 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5818 | 0.5701 |
Echinococcus granulosus | protein kinase C gamma type | 0.0271 | 0.4903 | 0.4661 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.9871 | 0.9868 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5818 | 0.5701 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0391 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5818 | 0.5701 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3318 | 0.3131 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0339 | 0.7769 | 0.7663 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0221 | 0.2771 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0339 | 0.7769 | 0.7663 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0339 | 0.7769 | 0.6127 |
Echinococcus granulosus | protein kinase c iota type | 0.0249 | 0.3966 | 0.368 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0314 | 0.6737 | 0.6583 |
Brugia malayi | Protein kinase c protein 2 | 0.0246 | 0.3803 | 0.3803 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.8684 | 0.8647 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0391 | 1 | 1 |
Onchocerca volvulus | 0.0293 | 0.5818 | 0.5 | |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0178 | 0.0937 | 0.0683 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0271 | 0.4903 | 0.4661 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0391 | 1 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0391 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0339 | 0.7769 | 0.6127 |
Echinococcus multilocularis | protein kinase c iota type | 0.0249 | 0.3966 | 0.368 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0221 | 0.2771 | 0.2429 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.45 mg kg-1 | Effective dose determined against rat adjuvant arthritis after peroral administration | ChEMBL. | 3875725 |
ED50 (functional) | = 52 mg kg-1 | Effective dose of the compound was determined by mouse phenyl-p-benzoquinone writhing (PQW)assay after peroral administration; activity value ranges from (22.9 - 118) | ChEMBL. | 3875725 |
ED50 (functional) | = 52 mg kg-1 | Effective dose of the compound was determined by mouse phenyl-p-benzoquinone writhing (PQW)assay after peroral administration; activity value ranges from (22.9 - 118) | ChEMBL. | 3875725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.