Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1301 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0363 | 0.1558 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.034 | 0.1355 | 0.0525 |
Onchocerca volvulus | 0.034 | 0.1355 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0479 | 0.2604 | 0.5 |
Onchocerca volvulus | 0.0287 | 0.0875 | 0.523 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0479 | 0.2604 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0363 | 0.1558 | 0.0749 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0479 | 0.2604 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.034 | 0.1355 | 0.8693 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0363 | 0.1558 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0363 | 0.1558 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0287 | 0.0875 | 0.5617 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0363 | 0.1558 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0363 | 0.1558 | 0.0749 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0363 | 0.1558 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0363 | 0.1558 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0363 | 0.1558 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0363 | 0.1558 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0479 | 0.2604 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0479 | 0.2604 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0479 | 0.2604 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.034 | 0.1355 | 0.0525 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1301 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.3 | Inhibition of MMP8 (unknown origin) | ChEMBL. | 17275314 |
Ki (binding) | = 50 uM | Inhibition of Matrix metalloproteinase-8 (Human neutrophil collagenase, MMP-8) | ChEMBL. | 9464365 |
Ki (binding) | = 50 uM | Inhibition of Matrix metalloproteinase-8 (Human neutrophil collagenase, MMP-8) | ChEMBL. | 9464365 |
log(1/Ki) (binding) | = 4.3 | Inhibition of MMP8 (unknown origin) | ChEMBL. | 17275314 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.