Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tissue type plasminogen activator | 0.0485 | 0 | 0.5 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0563 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0485 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0485 | 0 | 0.5 |
Onchocerca volvulus | 0.0563 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0563 | 1 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0563 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0485 | 0 | 0.5 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0563 | 1 | 1 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0563 | 1 | 1 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0563 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0485 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.5 mg kg-1 | Effective dose determined against rat adjuvant arthritis after peroral administration | ChEMBL. | 3875725 |
ED50 (functional) | = 20 mg kg-1 | Effective dose of the compound was determined by mouse phenyl-p-benzoquinone writhing (PQW)assay after peroral administration; activity value ranges from (9.2 - 43.6) | ChEMBL. | 3875725 |
ED50 (functional) | = 20 mg kg-1 | Effective dose of the compound was determined by mouse phenyl-p-benzoquinone writhing (PQW)assay after peroral administration; activity value ranges from (9.2 - 43.6) | ChEMBL. | 3875725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.