Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131775 | All targets in OG5_131775 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 467 aa | 449 aa | 27.6 % |
Brugia malayi | excitatory GABA receptor EXP-1A | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 473 aa | 441 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.2882 | 1 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.2882 | 1 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.2882 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.1325 | 0.4168 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0705 | 0.0705 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (binding) | 0 % | Efficacy against human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cells by whole-cell patch-clamp (No data) | ChEMBL. | 15177449 |
Efficacy (binding) | 0 % | Efficacy against human GABA-A receptor alpha3-beta3-gamma2 subunits expressed in L(tk-) cells by whole-cell patch-clamp (No data) | ChEMBL. | 15177449 |
Efficacy (binding) | = 15 % | Efficacy was determined against gamma-aminobutyric acid A receptor, alpha 1 expressed in Xenopus oocytes | ChEMBL. | 15177449 |
Efficacy (binding) | = 15 % | Efficacy was determined against gamma-aminobutyric acid A receptor, alpha 1 expressed in Xenopus oocytes | ChEMBL. | 15177449 |
Efficacy (binding) | = 55 % | Efficacy was determined against Gamma-aminobutyric acid A receptor, alpha 3 expressed in Xenopus oocytes | ChEMBL. | 15177449 |
Efficacy (binding) | = 55 % | Efficacy was determined against Gamma-aminobutyric acid A receptor, alpha 3 expressed in Xenopus oocytes | ChEMBL. | 15177449 |
Ki (binding) | = 0.31 nM | In vitro binding affinity against gamma-aminobutyric acid A receptor, alpha 1 expressed in L(tk) cells by displacement of [3H]-Ro-15-1788 | ChEMBL. | 15177449 |
Ki (binding) | = 0.31 nM | In vitro binding affinity against gamma-aminobutyric acid A receptor, alpha 1 expressed in L(tk) cells by displacement of [3H]-Ro-15-1788 | ChEMBL. | 15177449 |
Ki (binding) | = 0.61 nM | In vitro binding affinity against Gamma-aminobutyric acid A receptor, alpha 3 expressed in L(tk) cells by displacement of [3H]-Ro-15-1788 | ChEMBL. | 15177449 |
Ki (binding) | = 0.61 nM | In vitro binding affinity against Gamma-aminobutyric acid A receptor, alpha 3 expressed in L(tk) cells by displacement of [3H]-Ro-15-1788 | ChEMBL. | 15177449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.