Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0183 | 0.2874 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.006 | 0.0536 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0126 | 0.1796 | 0.1027 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.012 | 0.1673 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0033 | 0.0014 | 0.005 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0183 | 0.2874 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0033 | 0.0014 | 0.005 |
Echinococcus multilocularis | muscleblind protein | 0.0106 | 0.1401 | 0.1401 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0189 | 0.2997 | 0.0601 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0033 | 0.0014 | 0.005 |
Trypanosoma brucei | beta lactamase | 0.0177 | 0.2776 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0183 | 0.2874 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0106 | 0.1401 | 0.1401 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0183 | 0.2874 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0183 | 0.2874 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0183 | 0.2874 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0536 | 0.1865 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0177 | 0.2776 | 0.5 |
Echinococcus multilocularis | geminin | 0.0228 | 0.3751 | 0.3751 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.3751 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0183 | 0.2874 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.037 | 0.6453 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0014 | 0.005 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.037 | 0.6453 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.006 | 0.0536 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1401 | 0.4877 |
Echinococcus granulosus | muscleblind protein | 0.0106 | 0.1401 | 0.3736 |
Echinococcus granulosus | geminin | 0.0228 | 0.3751 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0106 | 0.1401 | 0.4877 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.3751 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0126 | 0.1796 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1401 | 0.4877 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0183 | 0.2874 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 7.2 | Inhibition of dihydrofolate reductase (DHFR) from E. coli. | ChEMBL. | 3882967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.