Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | microtubule associated protein 2 | 0.0837 | 0.6884 | 0.6724 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0189 | 0.1273 | 0.1273 |
Echinococcus granulosus | presenilin | 0.0201 | 0.138 | 0.0936 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0133 | 0.0791 | 0.0317 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0166 | 0.0166 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0189 | 0.1273 | 0.1273 |
Brugia malayi | Pre-SET motif family protein | 0.0252 | 0.1826 | 0.1826 |
Trichomonas vaginalis | set domain proteins, putative | 0.0287 | 0.2128 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0133 | 0.0791 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0166 | 0.0166 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0133 | 0.0791 | 0.0791 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.007 | 0.0251 | 0.0251 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0201 | 0.138 | 0.5433 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0166 | 0.0166 |
Echinococcus multilocularis | serotonin receptor | 0.0133 | 0.0791 | 0.0317 |
Toxoplasma gondii | hypothetical protein | 0.007 | 0.0251 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0189 | 0.1273 | 0.0824 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0467 | 0.3678 | 1 |
Echinococcus multilocularis | presenilin | 0.0201 | 0.138 | 0.0936 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0837 | 0.6884 | 0.6884 |
Brugia malayi | hypothetical protein | 0.0098 | 0.0489 | 0.0489 |
Brugia malayi | hypothetical protein | 0.007 | 0.0251 | 0.0251 |
Brugia malayi | hypothetical protein | 0.0098 | 0.0489 | 0.0489 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0201 | 0.138 | 0.138 |
Brugia malayi | Presenilin spe-4 | 0.007 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | presenilin spe-4 | 0.007 | 0.0251 | 0.0251 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0201 | 0.138 | 0.3516 |
Onchocerca volvulus | 0.0287 | 0.2128 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0489 | 0.0489 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1197 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0791 | 0.0791 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0189 | 0.1273 | 0.0824 |
Brugia malayi | Presenilin spe-4 | 0.007 | 0.0251 | 0.0251 |
Brugia malayi | hypothetical protein | 0.007 | 0.0251 | 0.0251 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0201 | 0.138 | 0.5433 |
Brugia malayi | Presenilin family protein | 0.0201 | 0.138 | 0.138 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0201 | 0.138 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0489 | 0.0489 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1197 | 1 | 1 |
Brugia malayi | Presenilin spe-4 | 0.007 | 0.0251 | 0.0251 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0837 | 0.6884 | 0.6724 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1197 | 1 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1197 | 1 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0467 | 0.3678 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0467 | 0.3678 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0201 | 0.138 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0252 | 0.1826 | 0.1826 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0791 | 0.0791 |
Brugia malayi | hypothetical protein | 0.007 | 0.0251 | 0.0251 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0201 | 0.138 | 0.5433 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes. | ChEMBL. | 10669561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.