Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vascular cell adhesion molecule 1 | Starlite/ChEMBL | References |
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | References |
Homo sapiens | intercellular adhesion molecule 1 | Starlite/ChEMBL | References |
Homo sapiens | selectin E | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | c4b binding protein beta chain | selectin E | 610 aa | 551 aa | 22.1 % |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | c4b-binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0026 | 0.1979 | 0.1966 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0026 | 0.1979 | 0.1966 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0026 | 0.1979 | 0.1966 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0128 | 0.0112 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Plasmodium falciparum | glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0273 | 0.0257 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0022 | 0.1256 | 0.1242 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0026 | 0.1979 | 0.1966 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.1979 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0.1979 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0026 | 0.1979 | 0.1966 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0591 | 0.0591 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0026 | 0.1979 | 0.1966 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0128 | 0.0128 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.1256 | 0.1242 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0.1979 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0014 | 0.0016 | 0.0016 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.085 | 0.0836 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0.1979 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0026 | 0.1979 | 0.1966 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.0016 | 0.5 | |
Plasmodium falciparum | thioredoxin reductase | 0.0026 | 0.1979 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0591 | 0.0575 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0015 | 0.0128 | 0.0112 |
Treponema pallidum | NADH oxidase | 0.0026 | 0.1979 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0015 | 0.0128 | 0.0112 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.085 | 0.0836 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0128 | 0.0128 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0014 | 0.0016 | 0.0016 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0.1979 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0.1979 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0.1979 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 4 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 4 nM | Inhibition of selectin E in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 4 nM | Inhibition of intercellular adhesion molecule-1 (ICAM1) in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 5 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
IC50 (binding) | = 5 nM | Inhibition of VCAM-1 in human endothelial cells | ChEMBL. | 11585452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.