Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SEA domain containing protein | 0.0035 | 0.0469 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0086 | 0.00000077447 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0116 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.053 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0116 | 0.003 |
Echinococcus multilocularis | MAM | 0.0037 | 0.0593 | 0.1681 |
Brugia malayi | Muscle positioning protein 4 | 0.0035 | 0.0469 | 0.0386 |
Onchocerca volvulus | 0.0222 | 0.9349 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0593 | 0.0596 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0037 | 0.0593 | 0.0511 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0593 | 0.0511 |
Echinococcus granulosus | aminopeptidase N | 0.009 | 0.3101 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0469 | 0.0471 |
Onchocerca volvulus | 0.0037 | 0.0593 | 0.0547 | |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0026 | 0.0086 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0036 | 0.053 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0036 | 0.053 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0593 | 0.0596 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0222 | 0.9349 | 0.9393 |
Onchocerca volvulus | 0.0035 | 0.0469 | 0.0413 | |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0026 | 0.0086 | 0.00000077447 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0026 | 0.0086 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0036 | 0.053 | 0.0533 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0026 | 0.0086 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0036 | 0.053 | 0.1473 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0035 | 0.0469 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.9349 | 0.9344 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0036 | 0.053 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0045 | 0.0952 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.053 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1843 | 0.1772 |
Brugia malayi | Peptidase family M1 containing protein | 0.009 | 0.3101 | 0.3041 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0469 | 0.0386 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0026 | 0.0086 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0234 | 0.9954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0116 | 0.003 |
Onchocerca volvulus | 0.0203 | 0.8484 | 0.9066 | |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.9349 | 0.9344 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0026 | 0.0086 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0026 | 0.0086 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0036 | 0.053 | 0.0448 |
Echinococcus multilocularis | aminopeptidase N | 0.009 | 0.3101 | 1 |
Onchocerca volvulus | 0.0037 | 0.0593 | 0.0547 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0073 | 0.2285 | 0.2218 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0036 | 0.053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0086 | 0.00000077447 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0086 | 0.00000077447 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0116 | 0.003 |
Entamoeba histolytica | aminopeptidase, putative | 0.0026 | 0.0086 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0469 | 0.0413 | |
Brugia malayi | Peptidase family M13 containing protein | 0.0036 | 0.053 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0116 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0086 | 0.00000077447 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0036 | 0.053 | 0.1473 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0593 | 0.0511 |
Onchocerca volvulus | 0.0035 | 0.0469 | 0.0413 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0593 | 0.0511 |
Brugia malayi | Protein kinase domain containing protein | 0.0037 | 0.0593 | 0.0511 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0026 | 0.0086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.053 | 0.0448 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0235 | 1 | 1 |
Onchocerca volvulus | 0.009 | 0.3101 | 0.3254 | |
Onchocerca volvulus | 0.0035 | 0.0469 | 0.0413 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0593 | 0.0511 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0026 | 0.0086 | 0.00000077447 |
Echinococcus granulosus | MAM | 0.0037 | 0.0593 | 0.1681 |
Onchocerca volvulus | 0.0035 | 0.0469 | 0.0413 | |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0026 | 0.0086 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0026 | 0.0086 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0026 | 0.0086 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0469 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0116 | 0.003 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0026 | 0.0086 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2659 | 0.2595 |
Brugia malayi | Trypsin family protein | 0.0222 | 0.9349 | 0.9344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CCIC50 (functional) | = 45 uM | Cytotoxicity against MT-4 cells was determined by using cytopathic effect assay | ChEMBL. | 9934466 |
CCIC50 (functional) | = 45 uM | Cytotoxicity against MT-4 cells was determined by using cytopathic effect assay | ChEMBL. | 9934466 |
EC50 (functional) | = 0.019 uM | Anti-HIV activity was determined in MT-4 cells in the presence of 0% human serum using cytopathic effect assay | ChEMBL. | 9934466 |
EC50 (functional) | = 0.042 uM | Anti-HIV activity was determined in MT-4 cells in the presence of 50% human serum using cytopathic effect assay | ChEMBL. | 9934466 |
Inhibition (binding) | = 82 % | Inhibition of HIV protease at 0.5 nM | ChEMBL. | 9934466 |
Inhibition (binding) | = 82 % | Inhibition of HIV protease at 0.5 nM | ChEMBL. | 9934466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.