Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | uridine phosphorylase | 0.2429 | 1 | 1 |
Loa Loa (eye worm) | uridine phosphorylase | 0.2429 | 1 | 0.5 |
Mycobacterium leprae | probable uridine phosphorylase | 0.2429 | 1 | 0.5 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.2429 | 1 | 1 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.2429 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.2429 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 uM | Effective dose of the compound was tested for its ability to act as B-cell mitogens (mitogenicity); NC indicates not calculated | ChEMBL. | 7932584 |
ED50 (functional) | NT 0 uM | Ability to stimulate the natural killer response in murine in vitro cell assays | ChEMBL. | 7932584 |
ED50 (functional) | = 168 uM | Augment antibody response of B cells to sheep red blood cell (SRBC) challenge (adjuvanticity) | ChEMBL. | 7932584 |
Max response (functional) | NT 0 % | Percent of maximum response was tested for its ability to stimulate the natural killer response in murine in vitro cell assays | ChEMBL. | 7932584 |
Max response (functional) | = 17 % | Percent of maximum response was tested for its ability to act as B-cell mitogens (mitogenicity) | ChEMBL. | 7932584 |
Max response (functional) | = 193 % | Percent of maximum response was tested to augment the antibody response of B cells to sheep red blood cell challenge | ChEMBL. | 7932584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.