Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1093 | 0.2404 |
Trypanosoma brucei | thymidine kinase | 0.0472 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0061 | 0.0825 | 0.1233 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0061 | 0.0825 | 0.0825 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.3758 | 0.7522 |
Echinococcus granulosus | thymidylate kinase | 0.0061 | 0.0825 | 0.1639 |
Schistosoma mansoni | hypothetical protein | 0.0244 | 0.4913 | 1 |
Giardia lamblia | Thymidine kinase | 0.0472 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0061 | 0.0825 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1093 | 1 |
Leishmania major | thymidylate kinase-like protein | 0.0061 | 0.0825 | 0.0825 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0472 | 1 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0472 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0046 | 0.0487 | 0.0508 |
Leishmania major | thymidine kinase, putative | 0.0472 | 1 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0061 | 0.0825 | 0.5 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0061 | 0.0825 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0472 | 1 | 1 |
Echinococcus multilocularis | thymidylate kinase | 0.0061 | 0.0825 | 0.1639 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.0825 | 0.1233 |
Trypanosoma brucei | RNA helicase, putative | 0.0244 | 0.4913 | 0.4455 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.1093 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.044 | 0.9285 | 1 |
Plasmodium vivax | thymidylate kinase, putative | 0.0061 | 0.0825 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1093 | 0.1808 |
Brugia malayi | follicle stimulating hormone receptor | 0.044 | 0.9285 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0046 | 0.0487 | 0.0675 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.3758 | 0.7522 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.1093 | 0.1093 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0472 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0044 | 0.0441 | 0.0409 |
Plasmodium falciparum | thymidylate kinase | 0.0061 | 0.0825 | 0.5 |
Echinococcus multilocularis | geminin | 0.0192 | 0.3758 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0472 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0061 | 0.0825 | 0.1233 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1093 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1093 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0044 | 0.0441 | 0.0543 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1093 | 0.1808 |
Chlamydia trachomatis | thymidylate kinase | 0.0061 | 0.0825 | 0.5 |
Echinococcus granulosus | geminin | 0.0192 | 0.3758 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1093 | 0.2404 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1093 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0041 | 0.0386 | 0.0388 |
Loa Loa (eye worm) | thymidylate kinase | 0.0061 | 0.0825 | 0.0537 |
Brugia malayi | thymidylate kinase | 0.0061 | 0.0825 | 0.0537 |
Schistosoma mansoni | thyroid hormone receptor | 0.0044 | 0.0441 | 0.0409 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0061 | 0.0825 | 0.0825 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0061 | 0.0825 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.