Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | uridine phosphorylase 1 | 0.2369 | 0.5 | 0.5 |
Mycobacterium leprae | probable uridine phosphorylase | 0.2369 | 0.5 | 0.5 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.2369 | 0.5 | 0.5 |
Loa Loa (eye worm) | uridine phosphorylase | 0.2369 | 0.5 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.2369 | 0.5 | 0.5 |
Schistosoma mansoni | uridine phosphorylase | 0.2369 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 27 uM | In vitro inhibitory activity against murine antibody response to T-cell independent B-cell antigen TNP-LPS (type I) | ChEMBL. | 9719606 |
IC50 (functional) | = 27 uM | In vitro inhibitory activity against murine antibody response to T-cell independent B-cell antigen TNP-LPS (type I) | ChEMBL. | 9719606 |
IC50 (binding) | > 50 uM | In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH) | ChEMBL. | 9719606 |
IC50 (binding) | > 50 uM | In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH) | ChEMBL. | 9719606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.