Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0738 | 0.1508 | 0.0785 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.1989 | 0.1306 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0871 | 0.2179 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.1989 | 0.2542 |
Loa Loa (eye worm) | ryanodine receptor | 0.0902 | 0.2338 | 0.4255 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.1989 | 0.2542 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0871 | 0.2179 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0592 | 0.0767 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.2415 | 1 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1525 | 0.5494 | 0.7141 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1525 | 0.5494 | 0.7141 |
Loa Loa (eye worm) | ryanodine receptor | 0.057 | 0.0655 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.1525 | 0.5494 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1956 | 0.7672 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1956 | 0.7672 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.0096 | 0.0175 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.