Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.0897 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0023 | 0.0418 | 1 |
Echinococcus granulosus | geminin | 0.0157 | 0.6833 | 0.9915 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.011 | 0.4606 | 0.4606 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0023 | 0.0418 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.011 | 0.4606 | 0.4606 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0897 | 0.0897 |
Echinococcus granulosus | jun protein | 0.0158 | 0.6891 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.5468 | 0.8003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0033 | 0.0897 | 0.1302 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.6683 | 0.6683 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0418 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0157 | 0.6833 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0222 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0158 | 0.6891 | 1 |
Echinococcus multilocularis | jun protein | 0.0158 | 0.6891 | 1 |
Schistosoma mansoni | jun-related protein | 0.0128 | 0.5468 | 0.8003 |
Brugia malayi | hypothetical protein | 0.0124 | 0.526 | 0.526 |
Schistosoma mansoni | hypothetical protein | 0.0157 | 0.6833 | 1 |
Brugia malayi | MH2 domain containing protein | 0.011 | 0.4606 | 0.4606 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0418 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0418 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0158 | 0.6891 | 0.6891 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0033 | 0.0897 | 0.1302 |
Echinococcus multilocularis | geminin | 0.0157 | 0.6833 | 0.9915 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.0897 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0418 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0222 | 1 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0158 | 0.6891 | 1 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0021 | 0.0021 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0418 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.0897 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0897 | 0.1313 |
Entamoeba histolytica | hypothetical protein | 0.0033 | 0.0897 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0033 | 0.0897 | 0.1313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.