Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Brugia malayi | Thioredoxin reductase | 0.0421 | 1 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0146 | 0.2803 | 0.2803 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0387 | 0.9108 | 0.9108 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0146 | 0.2803 | 0.2803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0146 | 0.2803 | 0.2803 |
Toxoplasma gondii | thioredoxin reductase | 0.0421 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0146 | 0.2803 | 0.2803 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0146 | 0.2803 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0421 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0387 | 0.9108 | 0.9108 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0039 | 0 | 0.5 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0421 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0146 | 0.2803 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0146 | 0.2803 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0146 | 0.2803 | 0.2803 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0146 | 0.2803 | 1 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0039 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0421 | 1 | 1 |
Onchocerca volvulus | 0.0039 | 0 | 0.5 | |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0146 | 0.2803 | 0.2803 |
Treponema pallidum | NADH oxidase | 0.0146 | 0.2803 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | glutathione reductase | 0.0421 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0107 | 0.179 | 0.179 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0421 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0146 | 0.2803 | 0.2803 |
Plasmodium falciparum | thioredoxin reductase | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0039 | 0 | 0.5 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0146 | 0.2803 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0421 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0146 | 0.2803 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0146 | 0.2803 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0421 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0421 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0421 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0146 | 0.2803 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Plasmodium vivax | glutathione reductase, putative | 0.0421 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0146 | 0.2803 | 1 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0146 | 0.2803 | 0.2803 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0421 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0146 | 0.2803 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0146 | 0.2803 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0039 | 0 | 0.5 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0039 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0421 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0146 | 0.2803 | 0.2803 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0107 | 0.179 | 0.179 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0146 | 0.2803 | 0.2803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.