Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Protein lozenge | 0.0067 | 0.0412 | 0.0385 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.086 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0126 | 0.0094 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0126 | 0.0143 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.086 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0033 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0182 | 0.1804 | 0.1765 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0126 | 1 |
Echinococcus granulosus | frizzled | 0.0037 | 0.0047 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1804 | 0.1765 |
Echinococcus granulosus | frizzled | 0.0037 | 0.0047 | 0.0012 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0123 | 0.1083 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1804 | 0.1765 |
Echinococcus multilocularis | smoothened | 0.082 | 0.9517 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0126 | 1 |
Echinococcus granulosus | frizzled | 0.0037 | 0.0047 | 0.0012 |
Brugia malayi | Hint module family protein | 0.0182 | 0.1804 | 0.1765 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.6068 | 0.6049 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0036 | 0.0036 | 0.5 |
Echinococcus granulosus | frizzled 4 | 0.0037 | 0.0047 | 0.0012 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0384 | 0.4244 | 0.7681 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0126 | 1 |
Onchocerca volvulus | 0.0535 | 0.6068 | 1 | |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0036 | 0.0036 | 0.5 |
Echinococcus granulosus | Desert hedgehog protein | 0.0671 | 0.7715 | 0.8099 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.4916 | 0.4892 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0384 | 0.4244 | 0.4438 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0126 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0119 | 0.1041 | 0.106 |
Echinococcus multilocularis | hedgehog | 0.0671 | 0.7715 | 0.8097 |
Leishmania major | C-8 sterol isomerase-like protein | 0.086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.086 | 1 | 1 |
Echinococcus granulosus | smoothened | 0.082 | 0.9517 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0126 | 0.0083 |
Brugia malayi | hypothetical protein | 0.0535 | 0.6068 | 0.6049 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0036 | 0.0036 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0126 | 0.0079 |
Schistosoma mansoni | lozenge | 0.0067 | 0.0412 | 0.0667 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0384 | 0.4244 | 0.4217 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0036 | 0.0036 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0123 | 0.1083 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.0803 | 0.9312 | 0.9309 |
Schistosoma mansoni | hypothetical protein | 0.0489 | 0.5511 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0123 | 0.1083 | 0.1093 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0123 | 0.1083 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.6068 | 0.6049 |
Echinococcus granulosus | frizzled 5 | 0.0037 | 0.0047 | 0.0012 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0384 | 0.4244 | 0.4217 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0384 | 0.4244 | 0.4432 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0126 | 0.0143 |
Loa Loa (eye worm) | runx1 | 0.0067 | 0.0412 | 0.0366 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0036 | 0.0036 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.