Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ADAMTS-like protease | 0.239 | 0.0413 | 0.0088 |
Brugia malayi | Hemopexin family protein | 1.0392 | 0.3139 | 0.4576 |
Brugia malayi | angiogenesis inhibito | 0.239 | 0.0413 | 0.0088 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.7793 | 0.2254 | 0.3118 |
Onchocerca volvulus | 1.0392 | 0.3139 | 0.4487 | |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 1.0464 | 0.3164 | 0.5 |
Brugia malayi | Matrixin family protein | 0.8591 | 0.2526 | 0.3566 |
Loa Loa (eye worm) | hypothetical protein | 0.246 | 0.0437 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.8591 | 0.2526 | 0.3925 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.8591 | 0.2526 | 0.3925 |
Mycobacterium ulcerans | hydrolase | 1.0464 | 0.3164 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.4774 | 0.1225 | 0.3114 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.3255 | 0.0708 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.8591 | 0.2526 | 0.3925 |
Loa Loa (eye worm) | hypothetical protein | 0.7793 | 0.2254 | 0.3503 |
Brugia malayi | Matrixin family protein | 0.8591 | 0.2526 | 0.3566 |
Onchocerca volvulus | Matrilysin homolog | 0.8591 | 0.2526 | 0.3469 |
Loa Loa (eye worm) | hypothetical protein | 0.2234 | 0.036 | 0.0559 |
Brugia malayi | Matrixin family protein | 0.8591 | 0.2526 | 0.3566 |
Brugia malayi | Matrixin family protein | 2.0063 | 0.6435 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 3.0527 | 1 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.3255 | 0.0708 | 0.0361 |
Onchocerca volvulus | 0.8591 | 0.2526 | 0.3469 | |
Brugia malayi | Matrixin family protein | 0.8591 | 0.2526 | 0.3566 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 1.0464 | 0.3164 | 0.4616 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.1212 | 0.0012 | 0.0018 |
Loa Loa (eye worm) | matrixin family protein | 1.9055 | 0.6091 | 0.9466 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.3255 | 0.0708 | 0.1252 |
Loa Loa (eye worm) | hypothetical protein | 0.9672 | 0.2894 | 0.4497 |
Loa Loa (eye worm) | hypothetical protein | 1.0464 | 0.3164 | 0.4917 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.9672 | 0.2894 | 0.9117 |
Schistosoma mansoni | hypothetical protein | 1.0392 | 0.3139 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 1.9055 | 0.6091 | 0.9389 |
Loa Loa (eye worm) | matrixin family protein | 2.0063 | 0.6435 | 1 |
Onchocerca volvulus | Matrilysin homolog | 2.0135 | 0.6459 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 1.0464 | 0.3164 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.