TDR Targets

Basic information

Technical information

TDR Targets ID: 2073484
Name: 1-[4-hydroxy-4-(1-methylimidazol-2-yl)piperid in-1-yl]-3-phenylpropan-1-one
MW: 313.394 | Formula: C18H23N3O2
H donors: 1 H acceptors: 3 LogP: 0.9 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCC(CC1)(O)c1nccn1C)CCc1ccccc1
InChi: 1S/C18H23N3O2/c1-20-14-11-19-17(20)18(23)9-12-21(13-10-18)16(22)8-7-15-5-3-2-4-6-15/h2-6,11,14,23H,7-10,12-13H2,1H3
InChiKey: RBKMDHZHGWBDCM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-hydroxy-4-(1-methylimidazol-2-yl)-1-piperidyl]-3-phenyl-propan-1-one
1-[4-hydroxy-4-(1-methyl-2-imidazolyl)-1-piperidinyl]-3-phenylpropan-1-one
1-[4-hydroxy-4-(1-methylimidazol-2-yl)piperidin-1-yl]-3-phenyl-propan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0063	0.0686	0.0686
Onchocerca volvulus		0.0063	0.0686	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0034	0.0099	0.0099
Loa Loa (eye worm)	GABA receptor subunit	0.0034	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Onchocerca volvulus		0.0063	0.0686	1
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Loa Loa (eye worm)	ACC-1 protein	0.0063	0.0686	0.0686
Brugia malayi	Cation transporter family protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0219	0.3829	0.5
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0063	0.0686	0.2596
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.003	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.0686	0.0686
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0063	0.0686	0.0686
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0219	0.3829	0.5
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0063	0.0686	0.0686
Echinococcus multilocularis	glycine receptor subunit beta	0.0063	0.0686	0.2596
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0063	0.0686	0.2596
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	ACC-1 protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0219	0.3829	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0063	0.0686	0.0686
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0034	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0219	0.3829	0.5
Loa Loa (eye worm)	hypothetical protein	0.0506	0.963	0.963
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0219	0.3829	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.2032	0.2032
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0219	0.3829	0.5
Echinococcus granulosus	glycine receptor subunit beta	0.0063	0.0686	0.2596
Schistosoma mansoni	neurotransmitter gated ion channel	0.0034	0.0099	0.1438
Onchocerca volvulus		0.0034	0.0099	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0034	0.0099	0.1438
Brugia malayi	excitatory GABA receptor EXP-1A	0.0063	0.0686	0.0686
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Brugia malayi	Cation transporter family protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0063	0.0686	0.0686
Onchocerca volvulus		0.0034	0.0099	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0063	0.0686	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0063	0.0686	0.2596
Echinococcus multilocularis	nAChR subunit	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0063	0.0686	0.2596
Onchocerca volvulus		0.0063	0.0686	1
Onchocerca volvulus		0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.003	0.0023	0.0023
Echinococcus multilocularis	glycine receptor subunit beta	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.003	0.0023	0.0023
Trichomonas vaginalis	hypothetical protein	0.0219	0.3829	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.003	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0063	0.0686	0.2596
Entamoeba histolytica	hypothetical protein	0.0034	0.0099	0.5
Onchocerca volvulus		0.0063	0.0686	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0219	0.3829	0.5
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0063	0.0686	0.2596
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Onchocerca volvulus	Putative nachr subunit	0.0063	0.0686	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0063	0.0686	0.2596
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0063	0.0686	0.0686
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0063	0.0686	0.2596
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.003	0.0023	0.0086
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0063	0.0686	0.0686
Loa Loa (eye worm)	LGC-31 protein	0.0063	0.0686	0.0686
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.003	0.0023	0.0331
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0063	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.0686	0.0686
Brugia malayi	Cation transporter family protein	0.0063	0.0686	0.0686
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0063	0.0686	0.2596
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0063	0.0686	0.0686
Echinococcus granulosus	nAChR subunit	0.0063	0.0686	0.2596
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.003	0.0023	0.0331
Schistosoma mansoni	nAChR subunit	0.0063	0.0686	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0034	0.0099	0.0099
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.003	0.0023	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0686	0.0686
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0063	0.0686	0.2596
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0063	0.0686	0.2596
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0063	0.0686	0.2596
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.003	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2272	0.2272
Echinococcus granulosus	nAChR subunit	0.0034	0.0099	0.0373
Onchocerca volvulus		0.0063	0.0686	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0063	0.0686	0.2596
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.016	0.2642	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.016	0.2642	0.2642
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0063	0.0686	0.0686
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0063	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.0686	0.0686
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.003	0.0023	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0063	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0686	0.0686
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0063	0.0686	0.0686
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0034	0.0099	0.1438
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0063	0.0686	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0219	0.3829	0.5
Echinococcus multilocularis	nAChR subunit	0.0034	0.0099	0.0373
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0063	0.0686	1
Echinococcus granulosus	glycine receptor subunit beta	0.0063	0.0686	0.2596
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0063	0.0686	0.2596
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0063	0.0686	0.0686
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.003	0.0023	0.0086
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0063	0.0686	0.2596
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0063	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0063	0.0686	0.2596
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0063	0.0686	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.016	0.2642	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0034	0.0099	0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3547781

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2073484