Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hemopexin family protein | 0.1459 | 0.377 | 0.573 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.097 | 0.2433 | 0.6455 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0086 | 0.0023 | 0.0023 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0183 | 0.0287 | 0.0761 |
Brugia malayi | Matrixin family protein | 0.1029 | 0.2596 | 0.3946 |
Loa Loa (eye worm) | matrixin family protein | 0.2282 | 0.6017 | 0.9146 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1029 | 0.2596 | 0.6886 |
Brugia malayi | Matrixin family protein | 0.1029 | 0.2596 | 0.3946 |
Loa Loa (eye worm) | hypothetical protein | 0.1029 | 0.2596 | 0.3946 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0214 | 0.0372 | 0.0566 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.1029 | 0.2596 | 0.4314 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.1459 | 0.377 | 0.6265 | |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0086 | 0.0023 | 0.0035 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1029 | 0.2596 | 0.3946 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0298 | 0.0452 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 0.3208 | 0.4877 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1029 | 0.2596 | 0.3946 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1253 | 0.3208 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.2488 | 0.6579 | 1 |
Brugia malayi | Matrixin family protein | 0.1029 | 0.2596 | 0.3946 |
Brugia malayi | Matrixin family protein | 0.2488 | 0.6579 | 1 |
Onchocerca volvulus | 0.1029 | 0.2596 | 0.4314 | |
Onchocerca volvulus | 0.0265 | 0.051 | 0.0848 | |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.0436 | 0.0662 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.2282 | 0.6017 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0115 | 0.0101 | 0.0101 |
Entamoeba histolytica | aminopeptidase, putative | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0183 | 0.0287 | 0.0287 |
Echinococcus granulosus | adam 17 protease | 0.0201 | 0.0337 | 0.0337 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0086 | 0.0023 | 0.0023 |
Echinococcus multilocularis | aminopeptidase N | 0.0265 | 0.051 | 0.051 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1253 | 0.3208 | 0.4877 |
Schistosoma mansoni | hypothetical protein | 0.1459 | 0.377 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0385 | 0.0837 | 0.1273 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0086 | 0.0023 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.1029 | 0.2596 | 0.3946 |
Mycobacterium ulcerans | hydrolase | 0.1253 | 0.3208 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0078 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1253 | 0.3208 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0265 | 0.051 | 0.051 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.2282 | 0.6017 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3742 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.1029 | 0.2596 | 0.3946 |
Brugia malayi | Peptidase family M1 containing protein | 0.0265 | 0.051 | 0.0776 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0115 | 0.0101 | 0.0101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.