Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.4133 | 1 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0013 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0114 | 0.2478 | 1 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0093 | 0.1971 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0013 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0093 | 0.1971 | 1 |
Echinococcus multilocularis | hedgehog | 0.0419 | 1 | 1 |
Echinococcus granulosus | smoothened | 0.0185 | 0.4227 | 0.4227 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.7195 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0093 | 0.1971 | 1 |
Brugia malayi | Hint module family protein | 0.0114 | 0.2478 | 1 |
Echinococcus multilocularis | smoothened | 0.0185 | 0.4227 | 0.4227 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0093 | 0.1971 | 1 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0093 | 0.1971 | 0.5 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0093 | 0.1971 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0013 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.