Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ras gtpase | 0.027 | 0.7974 | 1 |
Trichomonas vaginalis | dexras1, putative | 0.027 | 0.7974 | 1 |
Trichomonas vaginalis | ral, putative | 0.027 | 0.7974 | 1 |
Leishmania major | farnesyltransferase beta subunit | 0.0264 | 0.7363 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0289 | 1 | 1 |
Echinococcus granulosus | ras gtpase | 0.027 | 0.7974 | 1 |
Brugia malayi | Ras-related protein R-Ras2 | 0.027 | 0.7974 | 1 |
Entamoeba histolytica | ras-1, putative | 0.027 | 0.7974 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.027 | 0.7974 | 1 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.027 | 0.7974 | 1 |
Entamoeba histolytica | Ras family GTPase | 0.027 | 0.7974 | 1 |
Giardia lamblia | Prenyltransferase | 0.0264 | 0.7363 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.027 | 0.7974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.7974 | 1 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0264 | 0.7363 | 1 |
Trichomonas vaginalis | rap1 and, putative | 0.027 | 0.7974 | 1 |
Brugia malayi | Ras protein let-60 | 0.027 | 0.7974 | 1 |
Trichomonas vaginalis | rheb, putative | 0.027 | 0.7974 | 1 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0264 | 0.7363 | 0.5 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0264 | 0.7363 | 0.5 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0289 | 1 | 1 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0264 | 0.7363 | 0.5 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.027 | 0.7974 | 1 |
Trypanosoma brucei | lanosterol synthase | 0.0289 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.