Detailed information for compound 2074487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 376.491 | Formula: C24H28N2O2
  • H donors: 2 H acceptors: 1 LogP: 3.86 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c1CCO[C@@]3(c1[nH]2)CC[C@@](CC3)(N(C)C)c1ccccc1
  • InChi: 1S/C24H28N2O2/c1-26(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(27)8-9-21(20)25-22/h3-9,16,25,27H,10-15H2,1-2H3/t23-,24-
  • InChiKey: KFKGRKGKOJKTPF-RQNOJGIXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei lanosterol synthase 0.0644 1 1
Echinococcus granulosus ras gtpase 0.06 0.893 1
Trichomonas vaginalis rheb, putative 0.06 0.893 1
Trichomonas vaginalis ral, putative 0.06 0.893 1
Loa Loa (eye worm) hypothetical protein 0.06 0.893 1
Trichomonas vaginalis GTP-binding protein rit, putative 0.06 0.893 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0587 0.8607 1
Trichomonas vaginalis dexras1, putative 0.06 0.893 1
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0587 0.8607 0.5
Trypanosoma cruzi lanosterol synthase, putative 0.0644 1 1
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0587 0.8607 0.5
Trichomonas vaginalis rap1 and, putative 0.06 0.893 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0587 0.8607 0.8607
Trichomonas vaginalis ras-dva small GTPase, putative 0.06 0.893 1
Echinococcus multilocularis ras gtpase 0.06 0.893 1
Entamoeba histolytica Ras family GTPase 0.06 0.893 1
Loa Loa (eye worm) Ras protein let-60 0.06 0.893 1
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0587 0.8607 0.5
Entamoeba histolytica ras-1, putative 0.06 0.893 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0587 0.8607 0.8607
Entamoeba histolytica Ras family GTPase 0.06 0.893 1
Leishmania major farnesyltransferase beta subunit 0.0587 0.8607 1
Brugia malayi Ras protein let-60 0.06 0.893 1
Brugia malayi Ras-related protein R-Ras2 0.06 0.893 1
Giardia lamblia Prenyltransferase 0.0587 0.8607 0.5
Trypanosoma cruzi lanosterol synthase, putative 0.0644 1 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0587 0.8607 0.9639

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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