TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.504 | Formula: C21H31N5O
H donors: 1 H acceptors: 2 LogP: 5.22 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCc1ccc(cc1)c1noc(n1)[C@H]1CCCN1C(=N)N
InChi: 1S/C21H31N5O/c1-2-3-4-5-6-7-9-16-11-13-17(14-12-16)19-24-20(27-25-19)18-10-8-15-26(18)21(22)23/h11-14,18H,2-10,15H2,1H3,(H3,22,23)/t18-/m1/s1
InChiKey: JUZGDDYZTNXXNG-GOSISDBHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sphingosine kinase 1	Starlite/ChEMBL	References
Homo sapiens	sphingosine kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	sphingosine kinase A B	Get druggable targets OG5_128162	All targets in OG5_128162
Schistosoma japonicum	ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative	Get druggable targets OG5_128162	All targets in OG5_128162
Mycobacterium tuberculosis	Conserved protein	Get druggable targets OG5_128162	All targets in OG5_128162
Candida albicans	similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase	Get druggable targets OG5_128162	All targets in OG5_128162
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_128162	All targets in OG5_128162
Echinococcus granulosus	sphingosine kinase 1	Get druggable targets OG5_128162	All targets in OG5_128162
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128162	All targets in OG5_128162
Echinococcus multilocularis	sphingosine kinase 1	Get druggable targets OG5_128162	All targets in OG5_128162
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128162	All targets in OG5_128162
Candida albicans	similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase	Get druggable targets OG5_128162	All targets in OG5_128162
Schistosoma mansoni	sphingoid long chain base kinase	Get druggable targets OG5_128162	All targets in OG5_128162

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0205	0.0266	0.2368
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0064	0.005	0.0048
Echinococcus multilocularis	multidrug and toxin extrusion protein 2	0.004	0.0013	0.0011
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0119	0.0134	0.0136
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0119	0.0134	0.0136
Giardia lamblia	Hypothetical protein	0.0205	0.0266	1
Loa Loa (eye worm)	GABA receptor subunit	0.0064	0.005	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0299	0.0307
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0134	0.0132
Schistosoma mansoni	neurotransmitter gated ion channel	0.0055	0.0036	0.0312
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.0134	0.0132
Schistosoma mansoni	nAChR subunit	0.0055	0.0036	0.0312
Schistosoma mansoni	calcium-activated potassium channel	0.0369	0.0518	0.4774
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.2368
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0276	0.0376	0.0376
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0119	0.0134	0.0134
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.5352	0.8174	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0119	0.0134	0.1221
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0205	0.0266	0.0266
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Schistosoma mansoni	hypothetical protein	0.0369	0.0518	0.4774
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0055	0.0036	0.0035
Echinococcus granulosus	sphingosine kinase 1	0.0369	0.0519	0.0519
Entamoeba histolytica	hypothetical protein	0.0064	0.005	0.0644
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Onchocerca volvulus		0.0119	0.0134	0.3464
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0276	0.0376	0.0374
Schistosoma mansoni	sphingosine kinase A B	0.0369	0.0519	0.478
Entamoeba histolytica	hypothetical protein, conserved	0.0369	0.0519	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0205	0.0266	0.0265
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Brugia malayi	Cation transporter family protein	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Loa Loa (eye worm)	LGC-31 protein	0.0119	0.0134	0.0136
Loa Loa (eye worm)	glutaminase 2	0.0322	0.0446	0.0459
Onchocerca volvulus		0.0064	0.005	0.1255
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0736	0.1083	1
Schistosoma mansoni	sphingoid long chain base kinase	0.0369	0.0519	0.478
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0023	0.0026
Brugia malayi	hypothetical protein	0.0055	0.0036	0.0034
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0205	0.0266	0.0265
Schistosoma mansoni	neurotransmitter gated ion channel	0.0064	0.005	0.0443
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0736	0.1083	0.1081
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0205	0.0266	0.0266
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0134	0.0132
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0055	0.0036	0.0034
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Loa Loa (eye worm)	glutaminase	0.0322	0.0446	0.0459
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Mycobacterium ulcerans	putative regulatory protein	0.0531	0.0768	0.0416
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0276	0.0376	0.0376
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0205	0.0266	0.0273
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0736	0.1083	0.1083
Loa Loa (eye worm)	acetylcholine receptor protein	0.0055	0.0036	0.0035
Trypanosoma cruzi	hypothetical protein, conserved	0.0205	0.0266	0.2368
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0205	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Trypanosoma brucei	hypothetical protein, conserved	0.0205	0.0266	0.2368
Onchocerca volvulus		0.0281	0.0383	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0023	0.0026
Trypanosoma cruzi	hypothetical protein, conserved	0.0205	0.0266	0.2368
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0119	0.0134	0.0134
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0205	0.0266	0.2368
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Trypanosoma cruzi	hypothetical protein, conserved	0.0205	0.0266	0.2368
Brugia malayi	Cation transporter family protein	0.0119	0.0134	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0736	0.1083	1
Echinococcus granulosus	glycine receptor subunit beta	0.0119	0.0134	0.0134
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0205	0.0266	0.0265
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0369	0.0518	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.5352	0.8174	0.5
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.0134	0.0132
Leishmania major	hypothetical protein, conserved	0.0205	0.0266	0.2368
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0055	0.0036	0.0034
Echinococcus granulosus	nAChR subunit	0.0064	0.005	0.005
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.3561	0.5422	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.0134	0.0134
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0276	0.0376	0.0374
Toxoplasma gondii	hypothetical protein	0.0531	0.0768	0.0937
Schistosoma mansoni	nAChR subunit	0.0055	0.0036	0.0312
Echinococcus multilocularis	nAChR subunit	0.0119	0.0134	0.0132
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0205	0.0266	0.2294
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Leishmania major	hypothetical protein, conserved	0.0205	0.0266	0.2368
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.036	0.037
Onchocerca volvulus		0.0261	0.0352	0.9181
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0119	0.0134	0.0136
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0531	0.0768	0.0508
Schistosoma mansoni	neurotransmitter gated ion channel	0.0055	0.0036	0.0312
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0064	0.005	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0134	0.0132
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0055	0.0036	0.0034
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0205	0.0266	0.2368
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0064	0.005	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.5352	0.8174	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0205	0.0266	1
Loa Loa (eye worm)	hypothetical protein	0.5804	0.8869	0.9157
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.5352	0.8174	1
Onchocerca volvulus		0.0064	0.005	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0205	0.0266	0.2368
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0119	0.0134	0.0132
Giardia lamblia	hypothetical protein	0.0205	0.0266	1
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0055	0.0036	0.0036
Brugia malayi	hypothetical protein	0.0055	0.0036	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0531	0.0768	0.7026
Echinococcus multilocularis	Multi antimicrobial extrusion protein MatE	0.0037	0.0008	0.0006
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0119	0.0134	0.0134
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.2294
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0736	0.1083	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.0305
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0736	0.1083	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0119	0.0134	0.0132
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0736	0.1083	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0119	0.0134	0.0132
Loa Loa (eye worm)	PDE1B protein	0.0205	0.0266	0.0273
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0119	0.0134	0.0134
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0155	0.019	0.019
Schistosoma mansoni	acetylcholine receptor-related	0.0055	0.0036	0.0312
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0055	0.0036	0.0036
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0531	0.0768	0.0416
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0205	0.0266	0.2448
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0205	0.0266	0.2368
Brugia malayi	glutaminase DH11.1	0.0322	0.0446	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0266	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0369	0.0519	0.0534
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0205	0.0266	0.0265
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0119	0.0134	0.0134
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.0134	0.0134
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0119	0.0134	0.0132
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Toxoplasma gondii	hypothetical protein	0.0531	0.0768	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0266	0.0273
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.2294
Trichomonas vaginalis	conserved hypothetical protein	0.0531	0.0768	0.7026
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.036	0.0359
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0205	0.0266	0.0265
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0205	0.0266	0.0305
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0736	0.1083	1
Toxoplasma gondii	GAF domain-containing protein	0.0531	0.0768	0.0937
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.0134	0.1221
Echinococcus granulosus	multidrug and toxin extrusion protein 2	0.004	0.0013	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0205	0.0266	0.2294
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0276	0.0376	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0205	0.0266	0.0266
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0276	0.0376	0.0386
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0531	0.0768	0.0508
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Echinococcus granulosus	glycine receptor subunit beta	0.0119	0.0134	0.0134
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0023	0.0026
Brugia malayi	hypothetical protein	0.0055	0.0036	0.0034
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Plasmodium vivax	hypothetical protein, conserved	0.0531	0.0768	0.0937
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0134	0.0132
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0205	0.0266	0.0265
Echinococcus multilocularis	small conductance calcium activated potassium	0.0369	0.0518	0.0516
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.654	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Schistosoma mansoni	multidrug resistance protein	0.004	0.0013	0.0104
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0055	0.0036	0.0034
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.5352	0.8174	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0055	0.0036	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0383	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0205	0.0266	0.0265
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0055	0.0036	0.0312
Loa Loa (eye worm)	ACC-1 protein	0.0119	0.0134	0.0136
Trichomonas vaginalis	set domain proteins, putative	0.0261	0.0352	0.3099
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0281	0.0383	0.3526
Schistosoma mansoni	calcium-activated potassium channel	0.0291	0.0399	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0266	0.0273
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0205	0.0266	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0163	0.0167
Toxoplasma gondii	hypothetical protein	0.0531	0.0768	0.0937
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0055	0.0036	0.0034
Onchocerca volvulus		0.0055	0.0036	0.0885
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0736	0.1083	1
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.5352	0.8174	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0205	0.0266	0.2368
Onchocerca volvulus		0.0281	0.0383	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Mycobacterium ulcerans	putative regulatory protein	0.0531	0.0768	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0383	0.0394
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0205	0.0266	0.2368
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Brugia malayi	hypothetical protein	0.0055	0.0036	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0281	0.0383	0.3526
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0119	0.0134	0.0134
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Echinococcus multilocularis	nAChR subunit	0.0064	0.005	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0736	0.1083	0.1081
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Loa Loa (eye worm)	hypothetical protein	0.6335	0.9685	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.0134	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0036	0.0035
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.0134	0.0132
Loa Loa (eye worm)	ACC-1 protein	0.0119	0.0134	0.0136
Trichomonas vaginalis	conserved hypothetical protein	0.0531	0.0768	0.7026
Brugia malayi	hypothetical protein	0.0055	0.0036	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0187	0.0192
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0205	0.0266	0.0305
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0276	0.0376	0.0376
Echinococcus granulosus	nAChR subunit	0.0119	0.0134	0.0134
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0119	0.0134	0.0132
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0047	0.0047
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0119	0.0134	0.1221
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0055	0.0036	0.0034
Trichomonas vaginalis	glutaminase, putative	0.0322	0.0446	0.399
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.5352	0.8174	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0064	0.005	0.0048
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Loa Loa (eye worm)	hypothetical protein	0.0064	0.005	0.0049
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.2368
Plasmodium falciparum	phosphodiesterase delta, putative	0.0205	0.0266	0.0305
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0205	0.0266	0.0266
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Echinococcus granulosus	small conductance calcium activated potassium	0.0369	0.0518	0.0518
Brugia malayi	excitatory GABA receptor EXP-1A	0.0119	0.0134	0.0132
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0205	0.0266	0.2448
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.654	1	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0736	0.1083	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0159	0.0196	0.18
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0055	0.0036	0.0035
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0119	0.0134	0.0132
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0205	0.0266	0.2294
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Onchocerca volvulus	Putative nachr subunit	0.0276	0.0376	0.9815
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0229	0.0303	0.0311
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0119	0.0134	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Trypanosoma cruzi	hypothetical protein, conserved	0.0205	0.0266	0.2368
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0064	0.005	0.0048
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0205	0.0266	0.2294
Onchocerca volvulus		0.0119	0.0134	0.3464
Echinococcus multilocularis	glycine receptor subunit beta	0.0119	0.0134	0.0132
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0119	0.0134	0.0132
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0205	0.0266	0.0265
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.5352	0.8174	0.5
Schistosoma mansoni	glutaminase	0.0322	0.0446	0.411
Onchocerca volvulus		0.0281	0.0383	1
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0205	0.0266	0.2368
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0276	0.0376	0.0374
Trypanosoma cruzi	hypothetical protein, conserved	0.0205	0.0266	0.2368
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Mycobacterium ulcerans	hypothetical protein	0.0369	0.0519	0.0094
Schistosoma mansoni	nAChR subunit	0.0119	0.0134	0.1221
Plasmodium vivax	phosphodiesterase gamma, putative	0.0205	0.0266	0.0324
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0055	0.0036	0.0034
Onchocerca volvulus		0.0119	0.0134	0.3464
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0159	0.0196	0.0195
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0736	0.1083	1
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0205	0.0266	0.2368
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0205	0.0266	0.0266
Onchocerca volvulus		0.0055	0.0036	0.0885
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.2294
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0002	0.0002
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0276	0.0376	0.0374
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0736	0.1083	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0736	0.1083	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0205	0.0266	0.0324
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0055	0.0036	0.0034
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0119	0.0134	0.0132
Trypanosoma cruzi	hypothetical protein, conserved	0.0205	0.0266	0.2368
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0119	0.0134	0.0136
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0205	0.0266	0.2448
Brugia malayi	Pre-SET motif family protein	0.0229	0.0303	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0134	0.0136
Echinococcus multilocularis	sphingosine kinase 1	0.0369	0.0519	0.0517
Plasmodium falciparum	GAF domain-related protein, putative	0.0531	0.0768	0.092
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0736	0.1083	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0205	0.0266	0.0305
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0205	0.0266	0.0265
Echinococcus multilocularis	glycine receptor subunit beta	0.0119	0.0134	0.0132
Loa Loa (eye worm)	acetyltransferase	0.0159	0.0196	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0736	0.1083	0.1116
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0023	0.0023
Trichomonas vaginalis	conserved hypothetical protein	0.0531	0.0768	0.7026
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Brugia malayi	Cation transporter family protein	0.0281	0.0383	0.0381
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0064	0.005	0.0443
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0205	0.0266	0.0324
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0119	0.0134	0.0132
Onchocerca volvulus		0.0055	0.0036	0.0885
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0119	0.0134	0.0136
Brugia malayi	acetyltransferase, GNAT family protein	0.0159	0.0196	0.0195

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.3 uM	Inhibition of recombinant SK2 (unknown origin) expressed in Sf9 cells assessed as [33P]S1P formation using D-erythro sphingosine as substrate and gamma[33P]ATP by liquid scintillation counting	ChEMBL.	26780304
Ki (binding)	= 13 uM	Inhibition of recombinant SK1 (unknown origin) expressed in Sf9 cells assessed as [33P]S1P formation using D-erythro sphingosine as substrate and gamma[33P]ATP by liquid scintillation counting	ChEMBL.	26780304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3546834

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 2074712